A STUDY OF SERUM MDA & TAC IN PATIENTS OF CERVICAL CANCER
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 53
Abstract
BACKGROUND Cervical cancer (Cx Ca), the third most common cancer among women in the world, was responsible for 275,000 deaths in 2008, 88% of which occurred in developing countries and 159,800 in Asia1 (Ferlay J et al 2010). An oxidant-antioxidant imbalance and its involvement in the pathophysiology of Cx Ca and its associated complications can be overviewed. Aims & objectives- 1. To estimate serum level of total antioxidant capacity and MDA levels in patients with cervical cancer and compare it with healthy subjects. 2. To find correlation between serum total antioxidant capacity and MDA levels in cases of cervical Ca. MATERIALS & METHODS The study was conducted in 100 subjects out of which 50 were histopathologically confirmed cases of Cx Ca and 50 were healthy subjects (controls), within the age group of 25-65 years. The quantitative estimation of serum MDA was done by Satoh K method and that of Sr. TAC by Ferric Reducing Ability of Plasma (FRAP) according to the method of Benzie et al. Chi-square/Fisher Exact test has been used to find the significance of study parameters on categorical scale between two or more groups. Pearson correlation between serum TAC & MDA used to find the degree of relationship. RESULTS Our study found a significantly (p<0.001**) increased levels of serum MDA, and significantly (p<0.001**) decreased levels of serum TAC in cases as compared to controls. Our study also revealed a significant positive correlation between serum MDA & TAC (r= 0.026, p<0.001**) among patients of cervical cancer. CONCLUSION The patients of cervical cancer with altered antioxidant capacity and lipid peroxidation may play a contributory role in the pathophysiology of cervical cancer and its associated complications.
Authors and Affiliations
Saiqa Rasool Shah, Shrabani Mohanty, Asha G
Keywords
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- EP ID EP220884
- DOI 10.14260/Jemds/2017/871
- Views 84
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