A study of serum uric acid levels in essential hypertension
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 5
Abstract
Serum Uric acid (SUA) is an independent risk factor for cardiovascular and renal disease has been established by numerous epidemiological and experimental studies, particularly in patients with hypertension, heart failure or coronary heart disease, cerebral-vascular events in individuals with diabetes mellitus, and cardiac ischemia in hypertension. The mechanism(s) by which Uric Acid may engender organ damage is still incompletely understood, but there is increasing evidence that endothelial dysfunction is a fundamental mechanism whereby this substance may affect cardiovascular and renal function and structure. Hyperuricemia is a strong predictor of hypertension and BP progression. The aim of present study was to know the possibility of hyperuricemia causing hypertension, to see a relationship between the serum uric acid levels and severity and duration of hypertension. This study had been conducted in the Department of Biochemistry AIIMS Patna on adult patients who were referred from OutPatient Departments (OPD). Relevant demographic, personal, medical and surgical details of the patients are recorded in the department during their enrolment for biochemical investigations. Fifty (50) patients with the essential hypertension were retrieved from records they were considered as case study group. The fifty (50) normotensive age sex matched subjects were retrieved from records and they comprised as the control study group. The blood samples were analysed on fully automated clinical chemistry analyzer, Beckman Coulter AU 480. Serum uric acid (SUA) was estimated by Uricase method. Thus based on the study carried out we can conclude that Serum uric acid was elevated in hypertensive as compared to normotensive individuals. Serum uric acid can be used probably as an early biochemical marker to determine the severity of hypertension as stage 2 hypertensive had more elevation in serum uric acid levels as compared to other hypertensive.
Authors and Affiliations
Dr. Sushil Kumar, Dr. Mala Mahto, Dr. Ayan Banerjee, Dr. Ravi Kiriti, Dr. Alok Ranjan, Dr. Archana Bharti
Keywords
Related Articles
- EP ID EP586077
- DOI -
- Views 162
- Downloads 0
Assessment of the prevalence of subclinical and overt hypothyroid disorders in pregnancy with respect to maternal and fetal outcome
The prevalence of Subclinical Hypothyroidism in South Asia especially in India is more than in other parts of the world and mostly due to autoimmune thyroiditis and nutrition deficiency. The gravity of the complications...
Study of foetal and perinatal outcome in subclinical and overt hypothyroid disorders in pregnancy
In India thyroid disorders are in a transition zone from a predominant iodine deficient nation to now an iodine sufficient population. Rate of foetal loss is twice normal, there is increased risk of preterm delivery, 10...
Lowe syndrome (Oculocerebrorenal Syndrome): A case report
Lowe syndrome (Oculocerebrorenal syndrome of Lowe) is a rare X-linked recessive disorder characterized by the involvement of the eyes, brain, and kidneys. The causative gene is OCRL1. Survival rarely exceeds 40 years. I...
Original research article: A cross sectional study of primary adult glaucoma in an urban population of Rajasthan, India
Background: Glaucoma is a disease that damages your eye’s optic nerve. It usually happens when fluid builds up in the front part of your eye. That extra fluid increases the pressure in your eye, damaging the optic nerve....
Orally disintegrating tablets: A novel approach for medication
An orally disintegrating tablet (ODT) is a drug dosage form available for a limited range of over-the counter (OTC) and prescription medications. Orally disintegrating tablets differ from the traditional tablets, in that...