A Study of the Efficacy of Atorvastatin Alone and Its Combination with Omega-3 Fatty Acids in Patients with Hyperlipidemia

Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 8

Abstract

Atherosclerosis is one of the major causes of increased morbidity and mortality associated with coronary artery disease, cerebrovascular accidents, and peripheral vascular diseases. Dyslipidemia is one of the important causes that result in atherosclerosis. The incidence of atherosclerosis has been on the rising recently. Therefore prevention of dyslipidemia can decrease the development of atherosclerosis. Aims: The study was undertaken to determine the efficacy of atorvastatin alone and its combination with omega-3 fatty acids in the management of hyperlipidemia in patients attending a tertiary care hospital. Methods: This study was a cross-sectional prospective study conducted in the Department of Pharmacology and General Medicine, Kakatiya Medical College and Hospital, Warangal. The patients were selected from those visiting General Medicine OPD and diagnosed with hyperlipidemia. Sixty patients in the age group of 20 – 70 yrs, were recruited based on inclusion and exclusion criteria. They were divided into two groups. The Group I included the patients receiving Tab. Atorvastatin 10mg/day and Group II Atorvastatin 10mg/day plus Cap Omega-3 fatty acids 600mg/day for the duration of six months and follow up were done every month. Efficacy of treatment was assessed by the changes in laboratory parameters of Total cholesterol, Triglycerides, HDL-C, LDL-C, and VLDL-C. Results: The efficacy of combination therapy i.e., Atorvastatin plus Omega-3 fatty acids showed a statistically significant rise in HDL cholesterol with the mean percentage difference of 4.24% when compared to monotherapy with Atorvastatin. The efficacy of other parameters like total cholesterol (TC), LDL cholesterol, VLDL cholesterol, and triglycerides (TG'S) levels with the low dose of omega-3 fatty acids in combination therapy was not statistically significant and produced nearly identical alterations in serum lipoprotein levels when compared to monotherapy. Conclusion: Although statins are being used as first-line therapy for hyperlipidemia and in patients with elevated triglycerides. For patients with elevated LDL-C and low HDL-C combination therapy appears to be a better option. Thus omega-3 fatty acids may be a potential supplement for combination therapy apart from niacin and fibrates.

Authors and Affiliations

Dr. Madhukar Rao Polasani, Dr. Swathi C

Keywords

Related Articles

Identification of Cancer Marker Vinculin from Caco-2 Cancer Cell By Using UPLC/MS Method

Identification of Cancer Marker Vinculin from Caco-2 Cancer Cell By Using UPLC/MS Method Abstract:Vinculin is one the most common proteins that have been studied commonly in recent years.Vinculin has anti-tumor effect an...

Design, Development, Evaluation and Optimization of Microballoons of Telmisartan

Abstract:In present study an attempt was made to prepare microballoons of Telmisartan by emulsion solvent diffusion technique for sustained delivery by using polymers like Ethyl cellulose to extend the drug release for a...

Application of QbD Approach to Development and Validation of a Novel UV- Spectrophotometric Method for Quantitative Estimation of Quetiapine Fumarate in Bulk and Pharmaceutical Formulation (Tablets)

Abstract:Stability Indicating UV-spectrophotometric analytical method validation for the estimation of Quetiapine fumarate have already been reported, but no studies reported so far include the application of Analytical...

Antimicrobial Activity of Spilanthesacmellaand Its Chemical Composition

Abstract:In present study an attempt has been made to study the antimicrobial activity and chemical composition of leaves and flowers of Spilanthesacmella. The leaves and flowers of the plant were collected and subjected...

Characterization of Overall Quality of Olive Oil from Different Lebanese Regions

Abstract:This study aimed to determine the quality of Lebanese olive oil by analyzing their chemical composition and their physicochemical characteristics. Olive oil samples were first collected from three different Leba...

Download PDF file
  • EP ID EP481627
  • DOI -
  • Views 85
  • Downloads 0

How To Cite

Dr. Madhukar Rao Polasani, Dr. Swathi C (2018). A Study of the Efficacy of Atorvastatin Alone and Its Combination with Omega-3 Fatty Acids in Patients with Hyperlipidemia. Saudi Journal of Medical and Pharmaceutical Sciences, 4(8), 1059-1063. https://www.europub.co.uk/articles/-A-481627