A STUDY ON BEHAVIOURAL CHANGES INDUCED BY COLD WATER STRESS IN SWISS ALBINO MICE
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 3
Abstract
Introduction: Stressful condition induces physiological and behavioral changes in an organism to maintain the normal homeostasis. The response to stress is regarded as a positive adaptive process of an organism, which consist of a set of physiological and behavioral reactions to cope up with the challenging situations. In animals, stress study has shown to affect locomotor activities and behavioral changes. The present study was to determine the effect of cold water stress in different duration on neurobehavioral changes in swiss albino mice. Material and Methods: Male swiss albino mice weighing about 20 to 25gm were chosen for the study. The study consists of 4 groups (i) control, (ii) 1 day cold stress, (iii) 7 days cold stress and (iv) 14 days cold stress. The cold stress procedure was done by allowing the animal to swim in cold water at 14ï‚°C for 5minutes every day. After the stress period, the neurobehavioral parameters were studied by using open field behavior and elevated plus maze. Results: There was a significant decrease in ambulation, rearing, grooming with a significant (P<0.001) increase in immobilization time of 1 day cold stress exposed group and 7th day cold stress exposed group in open field behavior model, whereas the 14th day stress group showed a significant decrease in ambulation only. In elevated plus maze, time spent in open arm was significantly decreased in 1st and 7th day stress group (P<0.001) and the number of entries in open arms and closed arms was significantly decreased in all stress exposed groups when compared with their respective control groups. Conclusion: Cold stress can affect hypothalamic- pituitary adrenal axis and thereby increase anxiety resulting in change in behavior and locomotor activity. When the stress period was prolonged to 7-14 days, there was a gradual recovery back to near normal. This type of behavior of the animals to prolonged stress could be attributed to habituation of the hypothalamo-pituitary adrenal axis.
Authors and Affiliations
Suresh. M| Department of Physiology, Meenakshi Medical College Hospital & RI, Enathur, Kanchipuram, Tamilnadu, India, Chandrasekhar M| Department of Physiology, Meenakshi Medical College Hospital & RI, Enathur, Kanchipuram, Tamilnadu, India Corresponding author email: mchandru1959@hotmail.com, Nikhil Chandrasekhar| Department of Anesthesialogy, Meenakshi Medical College Hospital & RI, Enathur, Kanchipuram, Tamilnadu, India, Ambareesha Kondam| Department of Physiology, Meenakshi Medical College Hospital & RI, Enathur, Kanchipuram, Tamilnadu, India, Madhuri BA| Department of Physiology, Meenakshi Medical College Hospital & RI, Enathur, Kanchipuram, Tamilnadu, India, Gajalakshmi G| Department of Physiology, Meenakshi Medical College Hospital & RI, Enathur, Kanchipuram, Tamilnadu, India
Keywords
Related Articles
- EP ID EP11007
- DOI 10.5958/j.2319-5886.2.3.088
- Views 397
- Downloads 22
METALLO BETA LACTAMASE MEDIATED RESISTANCE IN CARBAPENEM RESISTANT GRAMNEGATIVE BACILLI: A CAUSE FOR CONCERN
Introduction: The emergence of acquired metallo-β-lactamases (MBL) in Gram-negative bacilli is becoming a therapeutic challenge, as these enzymes usually possess a broad hydrolysis profile that includes carbapenems, e...
EVALUATION OF UNDERGRADUATE MEDICAL STUDENTS’ LEARNING ENVIRONMENT IN GOA: A CROSS- SECTIONAL STUDY
Background: An increase in the medical student intake capacity from 100 to 150 seats in Goa Medical College during the academic year 2012-2013, led the author to assess the undergraduate Medical students’ learning en...
A study of changing trends in obstructive airway diseases & associated co-morbidities
Obstructive airway diseases (OAD), includes diseases characterized by increased resistance to airflow as a result of airway obstruction or airway narrowing. Types of obstructive lung diseases are asthma, COPD, bronchiec...
ASSESSMENT OF PROLIFERATIVE POTENTIAL OF TUMOR CELLS USING KI-67 EXPRESSION AND MORPHOMETRICAL ANALYSIS FOR PROGNOSTICATION OF ORAL SQUAMOUS CELL CARCINOMAS
Background: Cancer cells exhibit a characteristic intrinsic ability of uncontrolled cell proliferation which plays a vital role in tumor development and progression. The Ki-67 antigen expression is strictly associated...
A study on the incidence of preterm rupture of membranes in pregnant women caused by Mycoplasmahoministhrough comparison ofculture and PCR techniques in theAlavi Hospital of Ardabil Province
Mycoplasma hominis one of the smallest free-living prokaryotes that lack peptidoglycan in the cell wall. It is also a well-known pathogenic Mycoplasmain the human reproductive system that causes abortion, bacterial vagi...