A Study on Clinical, Laboratory Profile and Drug Sensitivity Pattern in Salmonella Positive Patients
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 1
Abstract
Abstract Introduction: Enteric fever is endemic and is a major public health burden in India. This study is conducted to assess the change in clinical presentation, morbidity and the sensitivity pattern to the drugs used in enteric fever. Aim: (1) To study the clinical presentation, laboratory features and sensitivity pattern of Salmonella positive patients in blood culture, (2) to analyze the treatment, complications, morbidity, and mortality related to the disease. Materials and Methods: It is a prospective observational study conducted in a Tertiary Care Medical College Hospital at Chennai between May 2014 and May 2016 in patients above 18 years of age who tested positive for Salmonella in blood culture. From the patient, details of history, clinical examination, investigations, and treatment were collected. Their antibiotic sensitivity pattern was recorded. Patients were followed up throughout the course of hospital stay and complications were also recorded. Defervescence of fever after antibiotics was also recorded. Results: A total of 76 patients were studied who were blood culture positive. Fever with vomiting, loose stools, headache, and cough were the common clinical manifestations of enteric fever. Absolute eosinopenia, mildly elevated liver enzymes with normal leukocyte count or leukopenia with neutrophilia can be a pointer for enteric fever. Nalidixic acid resistance (97.4%), return of susceptibility to chloramphenicol (98.7%), co-trimoxazole (98.7%), and ampicillin (88.2%) are other important findings in this study. Conclusion: There is a trend toward emerging resistance to 3rd generation cephalosporins due to increased defervescence time is seen in patients treated with cephalosporins. Common complications two decades ago causing high mortality and morbidity has reduced. However, other atypical presentations and complications involving other system sparing gastrointestinal system should be kept in mind due to antibiotic exposure prior hospitalization.
Authors and Affiliations
K Madhavan
Keywords
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