A Study on Efficacy and Safety of Silodosin in Geriatric Patients with Benign Prostatic Hyperplasia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Introduction: Benign prostatic hyperplasia(BPH) is a very common condition among elderly men causing significant symptoms with urination and results in bladder outlet obstruction. Silodosin is a recently developed selective α1A-adrenoreceptor antagonist for the medical treatment of BPH. This study is to evaluate the efficacy and safety of silodosin 8mg in geriatric patients with BPH. Materials And Methods: A prospective observational study was done at K.S.Hegde Medical Academy, Mangalore, India on 53 patients with BPH during August 2014 to march 2016. These patients were aged ≥ 50 years, with international prostate symptom score(IPSS) of ≥12 and having a peak urinary flow rate (PFR) <15 ml/sec on uroflowmetry. Patients were treated with silodosin 8mg once daily and were followed up. We assessed the changes in IPSS,PFR and adverse effects of the drug at baseline, 1 month and 3 months after treatment. Results: The mean age of subjects was 63.32±6.6. Their mean IPSS scores were 25.06±2.87,18.91±3.92, 16.19±4.9at baseline, 1month and 3 months respectively with significant improvement(p<0.0001). There was also a significant increase in the peak urinary flow rate(PFR) (p<0.0001). The only adverse effect encountered was retrograde ejaculation. In three out of 5 patients this problem subsided without any intervention. Conclusions: Silodosin is an effective and well tolerated drug producing significant improvement in IPSS and PFR with fewer cardiovascular side effects in this frail population. Therefore silodosin can be used as a first line agent in BPH and continuation of this drug will avoid a surgical intervention.
Authors and Affiliations
Dr. Chilukala Sai Praneeth, Dr. Rajeev T. P2, Dr. Shubhakar Bhandary, Dr. Chaitanya Reddy
Keywords
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- EP ID EP588899
- DOI 10.9790/0853-1601040611
- Views 111
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