A Study on Seroconversion in HBeAg Antigen Positive Chronic Hepatitis B Patients with Tenofovir Therapy

Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 9

Abstract

Introduction: Chronic Hepatitis B remains most important risk factor for developing cirrhosis, hepatic decompensation and hepatocellular carcinoma. So treatment with tenofovir of HbeAg positive Chronic Hepatitis B and seroconversion is the major concern. Aim: To see the HbeAg and HbsAg loss after receiving tenofovic therapy for 6 and 12 months. Methodology: A hospital based prospective study conducted on 50 chronic hepatitis B infection with HbeAg antigen positive patients between age group 12 to 60 years, receiving tenofovir (300mg) was taken for study. HbeAg, HbsAg and liver enzyme status was checked at the end of 6 months and 12 months. Results: ALT level became normal (<19mg/ml) in 37.5 % of female patients at the end of 12 months study and in male it was 67.65%. Overall biochemical response was 58%. All patients were HbeAg reactive at the end of 6 months of tenofovir therapy but 48 percent became non reactive at the end of 12 months. Overall seroconverson was 36 percent at the end of 12 months. Conclusion: There is statistical significant number of HbeAg loss, normalization of ALT level and HbeAg seroconversion at the end of 1 year. HBV DNA level became undetectable level in all sero converted groups.

Authors and Affiliations

Pinaki Nath

Keywords

Related Articles

Diagnostic Accuracy of Ultrasound in Malignant Testicular Swelling & Its Management-A Study of 34 Cases

Testicular swelling is a lump or a growth (mass) involving the genitalia is a common presentation in outdoor patients ranging from young to old. Occur in one or both the testicles. Proper diagnosis can prevent unnecessar...

Prevalence of Cardiac Autonomic Neuropathy among Type 2 Diabetes Mellitus in a Tertiary Care Centre

Background: Cardiac Autonomic Neuropathy (CAN) is one of the chronic complications of diabetes mellitus, with potentially dangerous outcomes. Though very frequent, it is one of the most under diagnosed and often overlook...

The Spectrum of Hydatid Disease in North Telangana: A Study of 17 Cases

Introduction: Hydatid disease or Echinococcosis is a zoonotic disease caused by the larva of Echinococcus species and is one of the oldest known diseases to man. The disease has a worldwide distribution and is also well...

Prevalence of urinary tract pathogen and its antimicrobial susceptibility pattern in children admitted in KMCH, Katihar, Bihar and compare its susceptibility pattern from national trend

Objective: This study was conducted to determine the prevalence of organism causing UTI, effect of gender & age on its prevalence, the antimicrobial susceptibility and resistance profile of bacterial isolates and compare...

Download PDF file
  • EP ID EP515061
  • DOI -
  • Views 122
  • Downloads 0

How To Cite

Pinaki Nath (2018). A Study on Seroconversion in HBeAg Antigen Positive Chronic Hepatitis B Patients with Tenofovir Therapy. Journal of Medical Science And clinical Research, 6(9), 390-396. https://www.europub.co.uk/articles/-A-515061