A STUDY ON THE HYPOGLYCAEMIC EFFECT OF TINOSPORA CORDIFOLIA IN ALBINO RATS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 23
Abstract
BACKGROUND Diabetes mellitus is a complex metabolic disorder, which has undergone elaborate research work and is still being studied widely the world over. Ayurvedic drugs have been widely used in its treatment from the time of Charaka and Sushruta. Tinospora cordifolia has been included among these. The present study was conducted in Streptozotocin-induced albino rats. MATERIALS AND METHODS A non-randomised controlled trial was used. The study was done in mature healthy rats in 6 groups with 6 in each group. Preliminary studies were done in normal rats. Fasting and random blood sugar levels in normal rats were determined. Minimum effective dose of fresh aqueous juice of Tinospora was calculated. Duration of hypoglycaemic effect was found out. Glucose tolerance test was done to compare the effectiveness of test, standard and normal. Detailed studies conducted in rats rendered mild and moderately diabetic by giving Streptozotocin. RESULTS Mean values of fasting and random blood sugar level in 25 normal rats was found to be 50.52 and 93.04 mg/dL respectively. Minimum effective dose was found out to be 400 mg/kg. Blood sugar level began to fall in first hour, maximum fall was noted in third hour and the values did not return to normal even after 6 hours. Comparative glucose tolerance test showed that there was no significant difference between the hypoglycaemic effect of test (Tinospora) and standard (Tolbutamide). There was highly significant difference between the hypoglycaemic effect of test (Tinospora) and control (Distilled water). Studies in diabetic rats (both mild and moderate) after a single dose showed that there was no significant difference between the hypoglycaemic effect of test (Tinospora) and standard (Tolbutamide). There was highly significant difference between the hypoglycaemic effect of test (Tinospora) and control (Distilled water). CONCLUSION There was significant reduction in blood sugar level in normal rats following a single dose of the drug, which did not return to normal after 6 hours. In Streptozotocin-induced diabetic rats (Mild and Moderate), similar effects were seen.
Authors and Affiliations
Mary Chacko P
Keywords
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- EP ID EP439361
- DOI 10.14260/jemds/2018/628
- Views 86
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