A STUDY ON VITAMIN D STATUS IN TUBERCULOSIS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 72
Abstract
BACKGROUND India is a country with the highest burden of TB. Vitamin D can lead to activation of immune system and prevent the growth of intracellular Mycobacterium tuberculosis. Good number of studies show that there is deficiency of Vitamin D in tuberculosis patients, though there are limited number of studies to show result on the contrary. This study was done with an aim to evaluate for any association of vitamin D with tuberculosis. MATERIALS AND METHODS The study was undertaken with 52 number of patients newly diagnosed with tuberculosis, diagnosed by clinical criteria and usual laboratory tests. Serum samples were collected and 25-hydroxy vitamin D level was estimated in all of them using chemiluminescent immunoassay technology and compared with that of normal healthy controls. RESULTS The study population included 52 patients (34 males and 18 females) diagnosed as TB, and healthy controls. 28 patients had pulmonary and 24 patients had extrapulmonary TB. Our study confirmed a high prevalence of vitamin D deficiency, 69.23% in patients with TB as compared to 34% of the healthy controls. The difference between the means were statistically significant with t=-2.41731 and p=0.008 (p<0.05). CONCLUSION Majority of the patients affected by tuberculosis demonstrated hypovitaminosis D in a greater proportion than the healthy controls. Though further large scale studies with patient followup are required to interpret the outcome of supplementation of vitamin D, it may be given as an add-on drug with antitubercular treatment.
Authors and Affiliations
Prathish Kumar Rajamanickam, Sujit Kumar Biswas, Giridhari Kar
Keywords
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- EP ID EP265543
- DOI 10.14260/jemds/2017/1105
- Views 80
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