A STUDY TO ASSESS THE USEFULNESS OF BRAIN NATRIURETIC PEPTIDE (BNP) AND OTHER PLASMA PARAMETERS AS BIOMARKERS TO CLASSIFY ISCHAEMIC STROKE SUBTYPES, ESPECIALLY CARDIOEMBOLIC
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 10
Abstract
BACKGROUND Globally, stroke is a major public health problem and as per the Global Burden of Diseases (GBD) study in 1990 stroke was the second leading cause of death worldwide. Subsequent efforts to update the GBD study reported nearly 5.87 million stroke deaths globally in 2010 as compared to 4.66 million in 1990. Objectives- To assess the usefulness of brain natriuretic peptide (BNP) and other plasma parameters as biomarkers to classify ischaemic stroke subtypes, especially cardioembolic. MATERIALS AND METHODS This prospective observational study was conducted in Department of Internal Medicine and Department of Neurology, LLR (Lala Lajpat Rai) Hospital and Associated Hospitals, GSVM Medical College, Kanpur (India), from October 2015 to September 2017. Random patients admitted to general ward of Medicine and Neurology Department willing to give informed consent and fulfilling requisite criterion for the study were included. RESULTS One hundred and eighty one patients of Acute Ischaemic Stroke had been screened during the study and finally 122 patients were included for analysis. There were 64 males (52.5%) and 58 (45.9%) females. The mean age of study subject was 60.73 ± 13.36 years with a male-to-female ratio of 1.10: 1. The most common acute ischaemic stroke subtypes was large artery atherosclerosis (65.5%) followed by small vessel disease (17.2%). The mean BNP level (pcg/mL) was highest in cardioembolic subtype. The mean level of GCS was highest in small vessel disease and lowest in other aetiology. The mean level of NIHSS was highest in cardioembolic subtype and lowest in undermined aetiology group. CONCLUSION The present study highlighted that Atherosclerotic AIS was the most prevalent type of AIS and Mean BNP levels were highest in Cardioembolic AIS and Cardioembolic stroke had the highest mean NIHSS and lowest mean GCS (excluding “other” aetiology).
Authors and Affiliations
Prem Singh, Mainak Deb, Alok Verma, Ashok Kumar Verma, Rinkita Deb Ganguly
Keywords
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- EP ID EP411323
- DOI 10.14260/jemds/2018/291
- Views 85
- Downloads 0
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