A Study to Determine Prevalance of Thyroid Disorders in Children and Adolescents with Vitiligo
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Background- Vitiligo is a common skin depigmenting disease, which is thought to have, at least partly, an autoimmune aetiology. The link between vitiligo and thyroid disease has been proved in adult patients. This association has scarcely been studied in children. Objectives- The purpose of this study was to assess the incidence of thyroid dysfunctions and autoimmune thyroiditis in children with vitiligo. The early diagnosis of clinical and subclinical forms of thyroid disease in these children and to facilitate early treatment and avoidance of the phenotypic manifestations of hypothyroidism. Methods- 110 children and adolescents (50 boys, 60 girls) with known vitiligo were enrolled. Serum free triiodothyronine, free thyroxine, thyroid-stimulating hormone, and antibodies to thyroperoxidase were measured. Thyroid gland efficiency was evaluated. Results- Twenty three (20.9%) out of 110 patients had abnormalities of thyroid function tests or thyroid autoantibodies or alterations in USG for thyroid. Previously reported prevalence of thyroid disease in children with vitiligo ranged from 10.7 to 24.1%, and the prevalence of 20.9% determined in our study was comparable with the literature. Conclusion- In paediatric patients with vitiligo, a significant incidence of thyroid dysfunction was found. Since vitiligo usually appears before the development of the thyroid disease, it may be useful to screen thyroid autoantibodies in all paediatric patients with vitiligo to assist in the early diagnosis and therapy of autoimmune thyroiditis. Also, the high rate of subclinical hypothyroidism determined in these patients attracted attention to the probable development of overt hypothyroidism in a long term
Authors and Affiliations
Aditi Dhanta
Keywords
Related Articles
- EP ID EP284977
- DOI -
- Views 67
- Downloads 0
Knowledge, Pattern and Practices of Breast feeding among mothers of rural and urban communities
Background: Breast milk is natural, economical and biological fluid considered as ideal nutrition for infants. World Health Organization (WHO) also recommends exclusive breast feeding (breast milk only, no water or other...
An Evaluation of the Metabolic Parameters in Women with Gestational Diabetes Mellitus after Delivery
Objective: To evaluate the metabolic parameters in women with gestational diabetes mellitus after delivery in north Indian women. Methods: This was a comparative study. A total of 50 patients were included in the study....
Tuberculosis –One of the Important Causes of Retroperitoneal Fibrosis in India
Introduction: Retroperitoneal fibrosis (RPF) is an uncommon condition in which a predominantly inflammatory plaque encasing the aorta, inferior vena cava, ureters, other retroperitoneal structures. A definitive etiology...
Influence of Cervical Collar on Vertebral Artery Blood Flow
Objective: This study was carried to determine the effect of hard cervical collar placement on vertebral artery (VA) lumen diameter (LD) and blood flow velocity parameters. Methods: In a sample of fifteen patients with c...
Double Trouble- Double Elevator Palsy With Pseudoptosis A Case Report
A monocular elevation deficiency is also known as Double elevator palsy. It suggests paralysis of both elevator muscles (the superior rectus and the inferior oblique) of same eye; resulting in clinical condition characte...