A Study to Evaluate the Role of Intravenous Immunoglobulin (IVIG) as an Adjuvant in the Management of Neonatal Sepsis in Preterm Babies
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2017, Vol 6, Issue 3
Abstract
Introduction: Newborn children conceived before 32 weeks of incubation are genuinely immune defcient with cord blood centralization of IgG being not as much as half contrasted with those found in infants conceived at full term. Furthermore, exceptionally preterm newborn children have lessened supplement components, polymorphonuclear chemotaxis and are obligated to debilitate their capacity pools. Aims and Objectives: This planned study has been attempted with the accompanying targets, to concentrate on the administration of IVIG in addition with antibiotics to improves the therapeutic consequence of sepsis in preterm neonates. Materials and Methods: Sixty preterm neonates with sepsis were randomly assigned into study and control groups at a tertiary level neonatal intensive care unit, Princess Esra Hospital and Owaisi Hospital & Research Centre, Deccan College of Medical Sciences, Hyderabad, Telangana, India. Study-group was given IVIG in addition to standard treatment. Results: Total 60 patients were enrolled, 30 in study and 30 in control group. There were no gender differences (male 50%, female 50%) of neonates enrolled, which is also evident in the study (males 47.7%, females 52.3%) and control group (males 52.3%, females 47.7%). Conclusion: Low levels of immunity in preterm neonates results in increased morbidity and mortality in severe infection. Use of IVIG along with the antibiotics and other supportive therapy can improve the outcome.
Authors and Affiliations
Awais Mirza| Department of Paediatrics, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Corresponding e-mail: awaismirza09@yahoo.com; nasir7crc@gmail.com, Uppin Narayan Reddy| Princess Esra Hospital and Owaisi Group of Hospitals, Hyderabad, Telangana, India, Altaf Naseem| Department of Paediatrics, Deccan College of Medical Sciences, Hyderabad, Telangana, India, Sumsam Ali Khurram| Department of Paediatrics, Deccan College of Medical Sciences, Hyderabad, Telangana, India
Keywords
Related Articles
- EP ID EP12337
- DOI -
- Views 354
- Downloads 11
Comparison of Mec A Gene in Staphylococcus Aureus Isolated from Children at Time of Admission and Discharge in West of Iran
Staphylococcus aureus (SA) is a species of the genus Staphylococcus that is found everywhere, including in the respiratory tract and on the skin of many adults and children, and that is considered one of the main pathog...
Is Insulin Pump a game changer in the management of Diabetes Mellitus: A case series
Prevalence of diabetes has drastically increased over the past decade and it has a debilitating effect on one’s quality of life. The Insulin Pump is a relatively new modality in the management of Diabetic patients. Th...
A CASE REPORT OF MOLLUSCUM CONTAGIOSUM INFECTION IN AN HIV INFECTED INDIVIDUAL
Molluscum contagiosum is a viral disease caused by mollusci pox virus (DNA virus).Seen commonly as disease in children and immunocompromised adults. Infection transmitted by direct skin to skin contact, fomites or sexu...
Assessment of clinical probability and death outcome of pulmonary embolism among ICU patients local experience from Saudi Arabia
Pulmonary embolism (PE) is serious event in medical and surgical practice. Many patients are admitted to the intensive care unit (ICU), and Few reports have addressed the outcome of patients with PE. Data were collected...
A CROSS SECTIONAL STUDY OF THE MORBIDITY PATTERN AMONG THE ELDERLY PEOPLE : SOUTH INDIA
Background: In 1950, just 8% of the world population was aged 60 years or over, by 2005 that proportion had risen to 10% and it is expected to be more than double over the next 45 years, reaching 22% by 2050. Evaluatio...