A trend of antibiotic resistance pattern of klebsiella pneumoniae isolated from various clinical samples in patients attending tertiary care hospital Saurashtra region, Gujarat, India
Journal Title: Medpulse International Journal of Microbiology - Year 2019, Vol 10, Issue 2
Abstract
Background: Klebsiella pneumoniae has been associated with different types of infections and one of the most important aspects of Klebsiella pneumoniae is emergence of multi-drug resistant strains. Moreover, extensive use ofbroad-spectrum antibiotics in hospitalized patients has led to both increased carriage of Klebsiella and the development of multidrug-resistant strains that produce extended-spectrum beta-lactamase (ESBL)Aims and Objectives:To know the prevalence of klebsiella pneumoniae infection. To know the trend of drug resistance pattern of Klebsiella pneumoniae isolates.To promote rational use of medicines to avoid antibiotic drug resistance.Materials and Methods: Out of35024total samples 2617 Klebsiella pneumoniae were isolated from various samples (blood, pus, sputum, urine) which were identified by phenotypic methods (Gram’s stain, colony morphology, biochemical reactions) from 2011-2014 were included in this study. These isolates were tested for antimicrobial drug sensitivity pattern by modified Kirby-Bauer disc diffusion method according to CLSI guideline.Results: Out of 35024 samples 2617 Klebsiella pneumoniae isolates were confirmed.1001 were isolated from blood culture, 775 were from pus, 533 were from urine and 308 were from sputum. As per our statistical data, 50% of isolates were multi-drug resistant. In antibiogran pattern, we found that most isolates were resistant to Ampicillin and Cephalothin; Gentamicin and Ceftazidime were moderately resistant and Piperacillin-tazobactum was least resistant.Conclusion:Our study concludes that there is overall increase in infection due to klebsiella pneumoniae strain and there is gradual increase in resistant klebsiella pneumoniae strain from the year 2011 to 2014.We strongly recommend that establish systems for monitoring antimicrobial resistance in hospitals to prepare treatment guideline policy.for pus samples; 66.67% in 2008, 61.11% in 2009 and 56.92% in 2010 for sputum samples and 78.31% in 2008, 74.44% in 2009 and 71.60% in 2010 for urine samples
Authors and Affiliations
Chintan Dalwadi, Hitesh Ahir
Keywords
Related Articles
- EP ID EP616972
- DOI 10.26611/10081023
- Views 80
- Downloads 0
Sociodemography and seroprevalence of hepatitis B, hepatitis C and Herpes Simplex virus infections among RTI/STI clinic attendees from a tertiary care hospital in Mumbai
Sexually Transmitted Infections are the most common infectious diseases worldwide and they present a huge burden of disease and adversely impact reproductive health of people. Worldwide over 340 million new cases occurre...
Prevalence of extended β lactamases, Amp C and metallo beta lactamases among gram negative clinical isolates at a tertiary care centre in South India
Background: Resistance of Gram negative bacteria to broad spectrum antibiotics is posing a clinical threat during the last decade. These ESBL and MBL producing organisms have a potential for rapid dissemination and hence...
Prevalence of dermatophytes and other fungal agents from clinical specimens at a tertiary care hospital
Background: Superficial fungal infections are the most common skin diseases, affecting millions of people throughout the world. The present study was undertaken to isolate dermatophytes and other fungal agents from clini...
Study of metallo-beta-lactamases (MBLs) producing pseudomonas aeruginosa in various clinical samples in tertiary care hospital
Pseudomonas is the epitome of an opportunistic pathogen, often causing Hospital acquired infection. It is well known that poor outcome occurs with serious indications due to MBL producing organisms are treated with antib...
Comparison of rapid test and conventional staining methods for the diagnosis of malaria in a tertiary care hospital
Rapid diagnosis is extremely important for effective treatment and reducing the mortality and morbidity of malaria. Therefore, study was undertaken to compare the efficacy of conventional staining methods (Leishman stain...