ABSORBANCE CORRECTION METHOD FOR SIMULTANEOUS DETERMINATION OF NEBIVOLOL AND AMLODIPINE BESYLATE IN COMBINED TABLET DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 8
Abstract
The manuscript describes validated absorbance correction method for the estimation of nebivolol and amlodipine besylate in combined dosage form. Absorbance correction method was based on property of additivity of absorbances. The two wavelengths on amlodipine besylate curve were found out where it showed same absorbance, which were 262 and 332.5 nm. At 332.5 nm, amlodipine besylate showed some absorbance while nebivolol showed zero absorbance. Both the drugs gave absorbance at 262 nm. The method involved solving of an equation based on measurement of absorbance at two wavelengths 262 and 332.5 nm. The determinations were made at 262 for nebivolol and amlodipine besylate and 332.5 nm for amlodipine besylate over the concentration range of 10-70 µg/ml for both nebivolol and amlodipine besylate with mean recovery of 99.7 ± 0.15 and 99.4 ± 0.18 % for nebivolol and amlodipine besylate, respectively by absorbance correction method. This method was found to be simple, sensitive, accurate, precise, reproducible, and economical and can be applicable for the simultaneous determination of nebivolol and amlodipine besylate in combined dosage form.
Authors and Affiliations
Satish Patel , Paresh Patel , Natavarlal Patel
Keywords
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