Activity of urine arylsulfatase A in brain-dead graft donors is a predictor of early and late graft function
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2017, Vol 71, Issue 0
Abstract
Objective: Human lysosomal arylsulfatase A (ASA) is a member of the sulfatase family. Arylsulfatase A is required to degrade sulfatides. Sulfatides occur in the myelin sheets of the central and peripheral nervous system. In this study we evaluated the urine activity of lysosomal enzyme arylsulfatase A in brain-dead donors as a marker and predictor of short – and long-term renal allograft function.Patients/Methods: We analyzed data from kidney recipients who received organs from brain-dead donors. Data from 40 donors and 68 recipients were analyzed.Results: Urine activity of arylsulfatase A in graft donors correlated positively with creatinine clearance in graft recipients after transplantation: significantly after 30 days (Rs=0.38, p=0.004) and after 3 years (Rs=0.38, p=0.03), and with borderline significance after 14 days (Rs=0.25, p=0.08) and after one year (Rs=0.23, p=0.07).Conclusions: The results of this study suggest that arylsulfatase A has a protective effect on kidney allograft, and the urine activity of this enzyme in kidney donors correlates positively with graft function.
Authors and Affiliations
Ewa Kwiatkowska, Leszek Domanski, Joanna Bober, Krzysztof Safranow, Andrzej Pawlik, Kazimierz Ciechanowski
Keywords
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