Acute and long term safety evaluation of Zincovit drop (Nutritional food supplement) in Wistar rats
Journal Title: GJRA-Global Journal For Research Analysis - Year 2015, Vol 4, Issue 8
Abstract
The aim of the present study was to investigate the acute and sub-chronic toxicity associated with Zincovit drop (Nutritional food supplement) in Wistar rats. Acute toxicity class method (OECD 423 guideline) was employed to determine acute toxicity in Wistar rats. Animals were observed individually after dosing daily for a total of 14 days. Sub chronic toxicity was investigated in normal control (2% gum acacia, 1 ml/kg/day) and Zincovit drop at 25, 100 and 400 mg/kg/day individually for 3 months in adult female Wistar rats (4 groups, n= 6). Clinical signs, hematological and biochemical parameters were assessed. During the acute toxicity study, according to annex 2a of OECD 423 guidelines, Zincovit drop falls under Category 4 (>300-2000) of globally harmonized classification system (GHS). For Zincovit drops, LD50 cut-off among Wistar rats was observed at 1000 mg/kg. There was no significant change in their body weight. During the 90 days of sub-chronic toxicity study, treatment with Zincovit drop among Wistar rats, the lowest-observedadverse- effect level (LOAEL) and no-observed-adverse-effect level (NOAEL) was observed at 400 mg/kg/day and 100 mg/kg/day respectively. The present study revealed the long term safety ofZincovit drop especially at 25 mg/kg/day and 100 mg/kg/day in Wistar rats.
Authors and Affiliations
SHAKTA MANI SATYAM, LAXMINARAYANA BAIRY KURADY
Keywords
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