Acute and Subacute Toxicological Assessment of the Leaf Aqueous Extract of Eremomastax speciosa (Acanthaceae) in Wistar Rats
Journal Title: Journal of Advances in Medical and Pharmaceutical Sciences - Year 2015, Vol 4, Issue 1
Abstract
Aim: The present study was carried out to investigate the possible toxic effects of the leaf aqueous extract from Eremomastax speciosa and also to evaluate the acceptable safety level of this extract in Wistar rats. Place and Duration of Study: Department of Animal Biology and Physiology, Faculty of Sciences of the University of Yaounde I, between September and December 2013. Methodology: The acute assay used 9 female rats distributed into 3 groups of 3 rats each. A control group received distilled water and the two test groups received by oral route a unique dose of the extract at 2000 mg/kg with 48 hours interval. In the subacute assay, 60 rats of both sexes were distributed into 6 groups of 10 rats each (5 males and 5 females) and received the extract by oral route for 28 days consecutively. The tests groups received the extract at doses of 400, 800 and 1600 mg/kg. The controls and satellite test groups received, respectively, distilled water and extract at the dose of 1600 mg/kg. Anthropometric, hematological and biochemical parameters were measured and histological sections of liver, kidneys and lungs were realized. Results: The results showed no signs of toxicity such as general behavior change, mortality or change in gross appearance of internal organs even at high dose (2 g/kg). In subacute toxicity assay few modifications were observed in hematological and biochemical parameters. Histopathology showed the presence of disturbances at the dose of 800 and 1600 mg/kg particularly in the females. Conclusion: The aqueous extract of the leaves of E. speciosa could be moderately toxic at high doses and adequate caution should be exercised in its use in ethnomedicine.
Authors and Affiliations
Gaël Tchokomeni Siwe, George Enonchong Enow-Orock, André Perfusion Amang, Christophe Mezui, Alain Bertrand Dongmo, Paul Vernyuy Tan
Keywords
Related Articles
- EP ID EP342623
- DOI 10.9734/JAMPS/2015/18361
- Views 115
- Downloads 0
In- vitro Evaluation of Antifungal Effects of Euphorbia abyssinica (Desert Candle) Extract
Aim: This study wastoevaluate extracts of Euphorbia abyssinicaa cactus-like plant of the family Euphorbiaceae commonly called desert candle or Kechiehbih by the kendem people of south-West Cameroon, for anti-fungal activ...
The Effect of Co-administered Drugs and Food on the Absorption of Artemether–Lumefantrine Tablet
The physicochemical properties of drugs, their dosage forms and routes of administration affect the rate and extent of drug absorption. Oral administration of drugs presents with variable absorption profiles due to multi...
Two Novel Alkylating Structural Analogues of Chloramphenicol Suitable for Topical Treatment of Dermal Neoplasms
Aims: To evaluate the efficacy of two alkylating structural analogues of chloramphenicol that have potential for application for treatment of dermal sited neoplasms. Study Design: Two compounds have been shown to alkylat...
Mucous Retention Cyst – Review of Literature and a Case Report
Mucocele is a mucin filled cavity and is one of the most common salivary gland pathology. It arises either due to severance of a duct or due to an obstruction to the salivary flow. In the former case, the more appropriat...
The Practice of Antibiotic Prophylaxis for Caesarean Delivery among Obtetricians and Trainee Obstetricians in Nigeria
Aims: Antibiotic prophylaxis is a recognized measure for preventing post-operative infection after Caesarean delivery and it is expedient that Obstetricians be aware and practice recommended regimen. This study aimed at...