Acute leukemia after cytotoxic treatment in a child with nephrotic syndrome
Journal Title: Indian Journal of Child Health - Year 2018, Vol 5, Issue 7
Abstract
Renal involvement in acute lymphoblastic leukemia (ALL) occurs due to several factors including leukemic infiltration of the kidneys, therapy-related side effects such as tumor lysis syndrome, nephrotoxic drugs, and septicemias. A 3-year-old boy with nephrotic syndrome (NS) who was previously treated with prednisolone and cyclosporine A for 14 months after the initial diagnosis of NS, presented to the emergency department with fever, breathing difficulty, generalized edema, and body pain with pallor, without evidence of lymphadenopathy, hepatosplenomegaly, petechiae, or purpura. On investigation, peripheral blood smear showed blast cells >80% and bone marrow aspiration showed complete replacement of the marrow with L1 lymphoblasts, consistent with a diagnosis of ALL. The exact mechanism of developing acute leukemia after cytotoxic treatment has not been established; the possibility must be considered that the incidence of this malignant disease is increased after cytotoxic treatment for nonmalignant diseases.
Authors and Affiliations
Manjari Tiwari, Arvind Kumar Shukla, Geetika Srivastava, Shrish Bhatnagar
Keywords
Related Articles
- EP ID EP466577
- DOI -
- Views 75
- Downloads 0
Dicephalic parapagus twin - A rare case report
We are reporting a rare case of a dicephalic parapagus twin born to multigravida mother diagnosed antenatally few hours before birth by ultrasonography. The baby was born by emergency cesarean section. The baby was full-...
Behavioral problems in children with steroid-sensitive nephrotic syndrome: An ignored aspect!
Background: Nephrotic syndrome (NS) is a common chronic renal disorder in children. Oral glucocorticoids are required in high doses for prolonged periods adding to various comorbidities including psychosocial issues and...
Bilateral ureteropelvic junction obstruction: Factors guiding management
Background: The management of prenatally detected hydronephrosis due to bilateral ureteropelvic junction obstruction (UPJO) remains controversial. No definite recommendations exist regarding management, and many authors...
Association of serum Vitamin A, calcium, alkaline phosphatase, and phosphorus levels with recurrent acute lower respiratory infections among children
Introduction: Acute lower respiratory infection (ALRI) is a leading cause of morbidity and mortality in children younger than 5 years of age all over the world especially in developing countries. Consequently, considerab...
Tetra-Amelia syndrome with congenital diaphragmatic hernia - A rare entity
Tetra-Amelia syndrome is a very rare disorder characterized by the absence of all four limbs. “Tetra” is the Greek word for “four” and “Amelia” refers to the failure of an arm or leg to develop before birth. This syndrom...