Acute renal failure induced by carbon tetrachloride in rats with hepatic cirrhosis
Journal Title: Annals of Hepatology - Year 2008, Vol 7, Issue 4
Abstract
Relationship between cirrhosis and renal dysfunction is not yet fully understood. A model of cirrhosis with acute hepatic and renal damage (RF), produced by CCl4 in rats, with hemodynamic and renal functional alterations, similar to those observed in decompensated cirrhosis (DC) in man, was used to study chemical nephrotoxicity in animals. We performed in male Wistar rats hepatic and renal functional and hemodynamic studies in control, cirrhotic and decompensated cirrhotic (DC) groups. Cirrhosis was induced with carbon tetrachloride by chronic administration. Association between liver and renal functional alterations was detected in rats with decompensated cirrhosis, showing fall in mean arterial pressure and reduction of glomerular filtration rate and filtration fraction. Renal hemodynamics did not change in cirrhotic rats, similarly to what occurs in compensated cirrhotic patients. However, DC rats exhibited increased sodium, glucose and phosphate urinary excretions and decreased ATP in renal cortex. DC animals had severe hypoglycemia. There was an extensive liver fibrosis. Glomeruli had hypercellularity and tubules showed extensive vacuolization in cirrhotic and DC rats. The present study suggests that in this model, damage typical of acute tubular necrosis ensues in cirrhotic rats. We describe functional and morphological damage in liver and kidney in a model of cirrhosis that might predispose to the development of acute renal failure when an individual with hepatic damage is exposed in acute way to chemical toxicants.
Authors and Affiliations
Fernando Jaramillo-Juárez, María Rodríguez-Vázquez;, Ana Rincón-Sánchez, María Consolación Martínez, Genaro Ortiz, Javier Llamas, Francisco Anibal Posadas, José Reyes
Keywords
Related Articles
- EP ID EP77806
- DOI -
- Views 172
- Downloads 0
Unusual cause of common bile duct dilatation in asymptomatic elderly patient: right hepatic artery syndrome
Andres Blei (Andy) October 1949-October 2008
Thymosin β10 as a predictive biomarker of response to 5-fluorouracil chemotherapy in cholangiocarcinoma
Introduction and aim. 5-Fluorouracil (5-FU) is the most commonly used chemotherapeutic drug in the treatment of cholangiocarcinoma (CCA). Since development of drug resistance to 5-FU in CCA patients is the primary cause...
SALLuting a new biomarker in hepatocellular carcinoma
Alkaline phosphatase normalization is a biomarker of improved survival in primary sclerosing cholangitis
Introduction. Recent studies suggest that serum alkaline phosphatase may represent a prognostic biomarker in patients with primary sclerosing cholangitis. However, this association remains poorly understood. Therefore,...