Adenosine Deaminase levels in Cerebrospinal fluid among Tubercular Meningitis patients
Journal Title: Scholars Academic Journal of Biosciences - Year 2015, Vol 3, Issue 11
Abstract
Abstract: Tuberculous Meningitis (TBM) is an endemic disease in developing countries, more so in low socio-economic status. CSF ADA (Cerebrospinal fluid Adenosine Deaminase) is thought to be released by T lymphocyte during cell mediated immune response to tuberculous infection. Adenosine deaminase (ADA) has been of interest for many years in TB diagnosis. The Present study has undertaken to know the levels of ADA in TBM and also comparison of ADA levels in TBM and other type of meningitis. This is a prospective study conducted in Siddhartha Medical College for one year. Based on CSF analysis meningitis cases were diagnosed and grouped in to various types. These CSF samples ADA levels are estimated. Statistical analysis has done with chi-square test. Children were most commonly affected in tubercular meningitis. The Mean CSF ADA levels are more in Tubercular Meningitis (28.7±9.2) followed by Pyogenic meningitis (17.8±7.7), Aseptic Meningitis (7.4±8.4) and Fungal Meningitis (5.7±5.1). CSF ADA levels cut-off value at 10 IU/L shown that sensitivity 96% and specificity 93.5% for the diagnosis of Tubercular Meningitis. CSF ADA levels estimation is a simple, rapid inexpensive, fairly sensitive and specific method. It also helps in early diagnosis and helps in differentiating tubercular meningitis and non tubercular meningitis. Keywords: Tubercular Meningitis, Adenosine Deaminase, Cerebrospinal fluid, Non tubercular meningitis.
Authors and Affiliations
Dr. Sundara Veena Nethala, Dr. Geethanjali Anke
Keywords
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