Advances in the role of T cells in colorectal cancer and related therapies

Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 9

Abstract

T cells are closely associated with tumor development and the homeostasis of the tumor microenvironment (TME). The co-receptors of immune checkpoints on the surface of T cells collectively regulate immune responses and can inhibit or kill tumor cells by secreting various substances, correcting and restoring impaired anti-tumor immune responses. In recent years, there has been some progress in targeted T cell therapy, but some new immune test targets are still being studied. This article focuses on the role of T cells in the regulation of colorectal cancer (CRC) and TME, the mechanism of immune resistance to CRC and its targeted therapy, and discusses the relevant effects of T cells on the occurrence and development of CRC and the application prospect of targeted T cell therapy for CRC.

Authors and Affiliations

LI Yuetian, HUANG Haining, CHEN Shuai, WANG Quanyi

Keywords

Related Articles

The predictive value of whole brain CT perfusion imaging and serum MMP-9 level in hemorrhagic transformation after acute cerebral infarction

"<b>Objective</b> To explore the value of whole brain CT perfusion (CTP) imaging parameters and serum MMP-9 level in predicting hemorrhagic transformation (HT) after endovascular therapy of acute cerebral infarction (ACI...

Current application of in-hospital informatized glucose monitoring system in Jiangsu

"<b>Objective</b> To investigate the application of in-hospital informatized blood glucose monitoring system (IGMS) in Jiangsu and the satisfaction of medical staff to use IGMS. <b>Methods</b> From August 2021 to July...

Application of pancreatic regenerating protein in early warning and diagnosis of diabetes mellitus

Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) are increasingly utilized in the treatment of type 2 diabetes, especially for their efficacy in weight reduction and improvement of cardiovascular and renal outcomes, a...

Development of navigation assisted minimally invasive spine surgery

In recent years, minimally invasive spine surgery (MISS) has gradually become a feasible, highly effective and popular method for the treatment of various spinal diseases. Compared to traditional open surgery, MISS has m...

Summary of best evidence for rehabilitation timing in patients undergoing arthroscopic rotator cuff repair surgery

"<b>Objective</b> To search,organize,and summarize the best evidence of rehabilitation timing for patients after arthroscopic rotator cuff repair surgery, providing reference for clinical practice. <b>Methods</b> Da...

Download PDF file
  • EP ID EP745449
  • DOI 10.13429/j.cnki.cjcr.2024.09.003
  • Views 49
  • Downloads 0

How To Cite

LI Yuetian, HUANG Haining, CHEN Shuai, WANG Quanyi (2024). Advances in the role of T cells in colorectal cancer and related therapies. Chinese Journal of Clinical Research, 37(9), -. https://www.europub.co.uk/articles/-A-745449