Advances in traditional Chinese medicine for liver disease therapy in 2020
Journal Title: Traditional Medicine Research - Year 2021, Vol 6, Issue 3
Abstract
Liver diseases are gradually becoming a serious threat to human health worldwide. Although a number of medications have been introduced for the prophylaxis, diagnosis, and treatment of liver diseases, several limitations and challenges remain. Traditional Chinese medicine is frequently used to treat liver diseases and well known to protect hepatocytes and inhibit inflammation, oxidative stress, and fibrosis. However, given the complex composition of traditional Chinese medicine, clarifying the mechanisms behind its curative and protective effects is difficult. In this review, research progress on traditional Chinese medicine for the treatment of liver diseases in 2020 is summarized on the basis of the literature available in the PubMed database. Herbal extracts derived from traditional Chinese medicine, including flavonoids, polysaccharides, saponins, and alkaloids, and Chinese medicinal formulas, such as the classic decoctions Chaihu Shugan powder, Linggui Zhugan decoction, and Huanglian Jiedu decoction, have shown promising therapeutic efficacy in liver disease treatment. We summarized the findings of several studies on the active ingredients of traditional Chinese herbs used for liver disease treatment in 2020, focusing mainly on their ability to confer antiviral effects to treat hepatitis, regulate antioxidant levels and apoptosis to treat liver injury, inhibit inflammation and improve dysfunctions in amino acids and energy metabolism to treat alcoholic liver disease, reduce hepatic lipid deposition to treat nonalcoholic fatty liver disease, promote activated hepatic stellate cells to treat liver fibrosis, inhibit the proliferation or promote the apoptosis of liver cancer cells to treat hepatocellular carcinoma, and improve bile acid metabolism to treat cholestasis.
Authors and Affiliations
Lu Yang, Jia-Bao Liao, An-Qi Liu, Xi Chen, Fei Qu, Huan-Tian Cui, Jing Miao
Keywords
Related Articles
- EP ID EP693638
- DOI 10.12032/TMR20210316225
- Views 139
- Downloads 0
Assessing acupuncture effect in the real world study
Acupuncture, with its unique set of theories and its evident results in clinical practice is an important part of traditional Chinese medicine (TCM), and gaining recognition worldwide for the past few years. Although acu...
Inner peace makes you live longer
The question of how we live longer—and why only a minority of humans have good health and a long life—has confused people for millennia. Over the past few decades, we have learned that human lifespan is determined by bot...
News and comments: The 2018 Sjöberg Prize awarded for the unique treatment of acute promyelocytic leukemia
In February 2018, the Royal Swedish Academy of Sciences decided to award the 2018 Sj?berg Prize to Zhu Chen (Shanghai Jiao Tong University, China), Anne Dejean (Institute Pasteur, Paris, France), and Hugues de Thé (Colle...
The protective effect of Dendrobium officinale polysaccharides on photoaging fibroblasts by scavenging reactive oxygen species and promoting the expression of TGF-β1
The purpose of this study was to explore the protective effect of Dendrobium officinale polysaccharides (DOP) on photoaging human skin fibroblasts and its specific mechanism of action. The photoaging fibroblast model was...
Evaluation of scientific evidence for abortifacient medicinal plants mentioned in traditional Persian medicine
Background: Miscarriage or spontaneous ending to a pregnancy takes place at the early stages of pregnancy without intervention. Pregnant women may use medicinal herbs to relieve some of the symptoms of pregnancy as they...