Advances of antibody-drug conjugates in the treatment of metastatic triple-negative breast cancer
Journal Title: Journal of Surgery : Concepts & Practice - Year 2024, Vol 29, Issue 6
Abstract
Triple-negative breast cancer (TNBC) is insensitive to endocrine therapy or anti-human epidermal growth factor receptor(HER)-2 targeted therapy due to its lack of expression of hormone receptors and HER-2. Antibody-drug conjugates(ADCs) recognize specific antigens on the surface of cancer cells through specific antibodies, form antigen-antibody complexes that are then internalized, and subsequently release their payloads to kill cancer cells, which offering a novel therapeutic option for metastatic TNBC. Currently, ADCs undergoing research and clinical application in metastatic TNBC include sacituzumab govitecan, datopotamab deruxtecan (Dato-DXd), SKB264, and trastuzumab deruxtecan (T-DXd). This article summarized the targets and structural characteristics of ADCs in metastatic TNBC, systematically reviewed the efficacy and safety of ADCs from relevant clinical studies, and discussed the issues of the clinical application of ADCs.
Authors and Affiliations
Yiwei TONG, Xiaosong CHEN
Keywords
Related Articles
- EP ID EP761815
- DOI 10.16139/j.1007-9610.2024.06.13
- Views 16
- Downloads 0
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