Age Related Lesions of Prostate in Men above 40 Years. An Autopsy Study
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 5
Abstract
Introduction: Prostate enlargement occurs in elderly men due to two causes, benign prostatic hyperplasia and prostatic carcinoma, which are sources of considerable morbidity and mortality. These two conditions are significant public health issues throughout the world. BPH is extremely common in men above 40years and its incidence is nearly 95% in men above 70 years. A rising incidence of microscopic foci of prostate cancer is found in men with increasing age. Results of autopsy studies have shown that almost 30% of men over the age of 50 have histological evidence of prostate cancer. Materials and Methods: This study involved 50 prostate specimens obtained by autopsy and their histological analysis. Results: The mean age in this study was 57.5years. Non neoplastic lesions studied were benign prostatic hyperplasia, atypical adenomatous hyperplasia, chronic prostatitis. Premalignant lesions were low grade prostatic intraepithelial neoplasia, and high prostatic intraepithelial neoplasia. The incidence of latent carcinoma was 12%. Conclusion: The lesions categorised in our study were non neoplastic, premalignant, and carcinoma. Non neoplastic lesions included benign prostatic hyperplasia, chronic prostatitis, basal cell hyperplasia, and atypical adenomatous hyperplasia, The incidence of was BPH (74%), basal cell hyperplasia (6%), atypical adenomatous hyperplasia (10%), and Chronic prostatitis was seen in ( 24%), low grade PIN (24%), high grade PIN ( 8%) in the total 50 specimens. The incidence of carcinoma is 12%.
Authors and Affiliations
Dr A. Sarath Kumar
Keywords
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