Aktywność biologiczna związków acetylenowych pochodzenia naturalnego
Journal Title: Wiadomości Chemiczne - Year 2016, Vol 70, Issue 9
Abstract
The natural acetylenic products containing at least one a carbon-carbon triple bond, are important class of compounds widely distributed in the environment. Development of spectroscopic techniques and methods for the isolation of metabolites allowed the extraction of natural acetylenic compounds. The most of these substances have been obtained from marine organisms, such as: cyanobacteria, algae and sponges. The next source of metabolites are herbal plants, which were used in the Chinese traditional medicine. A many of them show interesting biological activity. The first isolated natural compound possessing an acetylenic unit was dehydromatricaria ester, which was obtained from rhizome European goldenrod (Solidago virgaurea). To present day have been found and researched more than 2000 natural acetylenic metabolites. Due to the chemical structure, natural acetylenic compounds were divided into six groups: peptides, aromatic compounds, enediyne antibiotics, sterols, carotenoids, and poliacetylenic compounds . This article focuses natural acetylenic substances, which exhibit interesting biological properties, particularly anticancer ones. The review presents many of such metabolites, including fatty alcohols, ketones, acids, ethers, and carotenoids.
Authors and Affiliations
Monika Kadela-Tomanek, Elwira Chrobak, Ewa Bębenek, Agnieszka Lubczyńska, Szymon Siudak, Anna Wójcik
Keywords
Related Articles
- EP ID EP585055
- DOI -
- Views 138
- Downloads 0
Badanie oddziaływania wankomycyny z fragmentem peptydoglikanu ściany komórkowej bakterii
Unfortunately, despite of work involved in understanding of the mechanism of bacterial virulence, especially Staphylococcus aureus, it has not been developed effective therapy against this bacteria. The first antibiotic...
Metody syntezy pochodnych organicznych zawierających wiązanie potrójne węgiel-węgiel
Compounds containing triple bonds are lately in the centre of interest of many research groups. This is mainly connected with their usefulness as substrates to obtain complex compounds with various applications in differ...
Syntezy wybranych zasad Mannicha o aktywności przeciwbakteryjnej i przeciwgrzybiczej in vitro
The Mannich reaction is a three-component condensation reaction involving an active hydrogen containing compound, formaldehyde and a primary or a secondary amine. The Mannich reaction is one of the most important basic r...
Reakcje asymetrycznego otwierania pierścienia azyrydyn
Aziridines, the nitrogenous analogues of epoxides, are useful building blocks for the synthesis of various functional materials and biologically active compounds. The reactivity of aziridines toward ring opening and expa...
Trans-1,2-diaminocykloheksan – niezwykła kariera outsidera
An enantiopure trans-1,2-diaminocyclohexane is one of the most widely used chiral diamines in modern organic chemistry. This chiral building block, readily available from waste industrial products, emerges as a major fig...