Allogeneic Stem Cell Transplantation to cure Acute Myeloid Leukemia in elderly patients
Journal Title: Journal of Advances in Internal Medicine - Year 2012, Vol 1, Issue 1
Abstract
Outcomes for elderly patients with acute myeloid leukemia (AML) remain poor with standard therapies. Historically this age group has been excluded from treatment with allogeneic stem cell transplantation (allo-SCT) due to worries of excessive treatment related morbidity and mortality. However, transplantation outcomes have dramatically improved in the last decade due to the widespread use of less ablative conditioning regimens, improved supportive care, and improved patient selection based on prognostic tools such as the hematopoietic cell transplant specific comorbidity index. These have all led to an increasing acceptance of allo-SCT as a potential treatment modality in elderly patients with AML. This review addresses current strategies for patient selection and efficacy data for allo-SCT in elderly patients with AML.
Authors and Affiliations
Pritesh Patel*| Section of Hematology/Oncology and University of Illinois Cancer Center, University of Illinois Hospital and Health Science System, Chicago, USA, Santosh Saraf| Section of Hematology/Oncology and University of Illinois Cancer Center, University of Illinois Hospital and Health Science System, Chicago, USA, Damiano Rondelli| Section of Hematology/Oncology and University of Illinois Cancer Center, University of Illinois Hospital and Health Science System, Chicago, USA
ALLELOPATHIC EFFECTS OF ANACARDIUM OCCIDENTALE LINN OF TERENGGANU AND KELANTAN ON GROWTH OF MAIZE AND CUCUMBER
A study was conducted on Anacardium occidentale Linn. (Cashew) from Terengganu and Kelantan states of Malaysia, with the aim to determine the allelopathic effects of leaf and root extracts on the growth of bioassay plant...
RESPONSE OF CANOLA (BRASSICA NAPUS L.) CULTIVARS TO SOWING DATE AND ROW SPACING
The effect of sowing date (SD) and row spacing (RS) on canola (Brassica napus L.) cultivars was studied in a field experiment conducted for two years (2000-2002). The experiment was a randomized complete block design arr...
CONSTRAINTS IN PRODUCTION AND MARKETING OF PAPAYA IN RAIPUR DISTRICT OF CHHATTISGARH
This study aims to define the critical constraints in production and marketing of papaya in Raipur district of Chhattisgarh. The five villages of Dharshiwa block namely Chandandih, Tendua, Bhatagaon, Datrenga and Kathadi...
Prevalence of Helicobacter pylori infection, its correlation with gastroduodenal diseases and the incidence of gastric cancer in Nepal
Background and aims: The Helicobacter pylori (H. pylori) prevalence in Asian countries is highly variable, with higher seroprevalence shown in the previous studies of developing Asian countries. We aimed to determine the...
-119C/G in MYG1 Gene and 49A/G in CTLA4 Gene Polymorphisms in Turkish Patients with Vitiligo
Vitiligo is a disease characterized by sharply limited white macular depigmentation as a result of melanocyte loss. Disease is divided into three types according to prevalence and localization as localized, general and u...