Alpha -1-antitrypsin deficiency, associated diseases and treatments: a review
Journal Title: Pakistan Journal of Pharmaceutical Research - Year 2017, Vol 3, Issue 2
Abstract
Alpha-1-antitrypsin (AAT) is produced in the liver and one of its most important function is to protect the lungs from the neutrophils elastase level enzymes, normal level of AAT in the blood is 1.5-3.5gm/ml, when the AAT is up to 60% the lungs function normally but when it drops below 15% patients are likely to develop Emphysema and liver cirrhosis. Alpha 1-antitrypsin deficiency is heterogeneous genetic disorder due to mutation of chromosome no 14q32.1 (SERPINA1) that leads to the protease anti-protease imbalance. Alveolar And hepatocyte damage were observed causes which is due to the deficiency of Alpha 1-antitrypsin. Disease effects every system of body like respiratory, hepatic and biliary. The aim of study is to evaluate various diseases associated with AATD. Data was collected from internet using sciencdirect.com, googlescholar.com, pubmed.com. The most common associated diseases with alpha 1 antitrypsin deficiency are emphysema, asthma, liver cirrhosis and hepatitis depending the deficiency level of AAT. The best treatment is considered the adminstration of anticholinergics and ipratropium bromide improves the lung functions, however use of bronchodilators improves asthmatic attack also vaccination is carried to prevent the Hepatitis and liver cirrhosis.
Authors and Affiliations
Rauf-ur- Rehman
Keywords
Related Articles
- EP ID EP511648
- DOI -
- Views 123
- Downloads 0
Design Expert based Optimization and Permeation Study of Novel Topically Applied Anti-acne gel
In present study, Propylene glycol (PG) and Polyethylene glycol (PEG) were used as permeation enhancers to increase percutaneous absorption and release of CCT gel through silicone membrane. Gel formulations containing Cl...
Survey of socio-demographic prevalence, risk factors and clinical characterization of tuberculosis in Nishtar Hospital Multan
Tuberculosis is a worldwide health problem affecting one third of world’s population and Pakistan is no exception. In this study, we used a structured and close-ended questionnaire to collect data about sociodemographic...
Oral controlled release drug delivery system and Characterization of oral tablets; A review
Oral route of drug administration is considered as the safest and easiest route of drug administration. Control release drug delivery system is used as emerging tool in the development of pharmaceuticals. The oral route...
Dapoxetine: An Innovative Approach in the Therapeutic Management in Animal Model of Depression
Stress is a complicated condition that effects on person’s mental and physical health, and it is the precursor of other psychological disorders mainly depression. Serotonin (5-Hydroxytryptamine; 5-HT) is well known to ha...
Antimicrobial and antioxidant activity of Embelia robusta: a common adulterant in black pepper
The present study was aimed to investigate the phytochemicalas well as the antibacterial, antifungal, antioxidant and irritant activities of fruit of Embelia robusta. Agar-well diffusion method was used for antimicrobial...