ALTERATION IN UTERINE HISTOARCHITECTURE AND UTERINE PROTEIN FOLLOWING BUTYLPARABEN EXPOSURE IN ADULT MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 2
Abstract
Environmental chemicals with estrogenic properties are widely found in products widely used by human. Butylparaben (BuPben), a chemical with estrogenic activities is found to have adverse effects on the female reproductive tract. Adult mice were exposed to 10 mg, 50 mg and 100mg dose of BuPben for 7 and 21 days. In the study 0.001 mg/Kg body weight 17β estradiol was used as positive control and Olive oil and olive oil + ethanol (1:10) was used as control and vehicle control respectively. Subcutaneous exposure to 50 mg/kg body weight (bw) and 100 mg/kg bw of BuPben is found to cause significant increase in uterine weight when compared to control and vehicle control group in adult mice. In this study 50mg and 100 mg dose of BuPben, similar to 17 β estradiol (E2) (used as positive control) showed increase in thickness of myometrium and endometrium with adverse effects on uterine histology. Increase in number of uterine glands in also reported by all the doses of BuPben including 10 mg, 50 mg and 100mg when compared to control groups, along with significant decrease in concentration of serum estradiol and serum progesterone. Increase in uterine protein was also found in the study following BuPben exposure. Thus BuPben exposure adversely affects uterus in mice. This adverse effect of the chemical describes estrogenic activity of the chemical which may lead to reproductive failure in human and animals which gets exposed to the chemical.
Authors and Affiliations
Pallabi Goswami , J. C Kalita
Keywords
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