Alteration of Gene Expression Due to Arsenic Induced Oxidative Stress Leading to Ovarian Cancer
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 1
Abstract
Epidemiological studies and preventive measures for cancer have engaged most of the scientists and doctors for several decades and the research has come forth a long way now. Several heavy metals like arsenic have been linked with different types of cancer, one of which is ovarian cancer (Oca). Higher mortality rate of Oca signifies the gravity of the case. Moreover, arsenic is also believed to invoke generation of free radical and the consequences are even exacerbated. Early diagnosis of Oca is presently quite feeble and CA-125 alone seems to be insufficient and capricious. However, CA-125 along with other diagnostic parameter satisfies most of the pathologists and clinicians. For determination of oxidative stress, Malondialdehyde (MDA) was chosen as the marker and arsenic estimation was performed with the help of Atomic Absorption Spectrometer (AAS). RBC count, Heamoglobin, SGPT, SGOT and Alkaline phosphatase levels were performed according to standard protocol. Higher level of arsenic increases MDA level, decreases CA-125 level, decreases RBC and Haemoglobin level and increases SGPT, SGOT, ALP levels and vice versa for no arsenic in the Oca patients with significance <0.0001, <0.001, <0.005, <0.020, <0.001, >0.05, and <0.002 respectively. Concludingly, arsenic is one of the major causative agents for oxidative stress and hence leading to cancer including Oca. CA-125 was estimated to be very higher in Oca patients than normal ones and RBC count, Heamoglobin, SGPT, SGOT, ALP levels also seemed to be varied from normal.
Authors and Affiliations
Akhileshwari Nath
Keywords
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