Alterations in the invasive properties of peripheral blood monocytes from patients with endometriosis

Journal Title: Clinical and Experimental Obstetrics & Gynecology - Year 2019, Vol 46, Issue 1

Abstract

Purpose of this Investigation: The primary aim of this pilot study was to determine if the increase in monocyte/macrophage number in the peritoneal cavity of women with endometriosis is due to differences in peritoneal fluid signaling content (e.g. cytokine levels) or inherent differences in monocyte migration in response to those signals. Materials and Methods: Peripheral blood and peritoneal fluid samples were collected from endometriosis and surgical control patients at the time of surgery. Peripheral blood was also collected from a group of healthy ‘non-surgical control’ patients in an internal medicine clinic. Monocytes were isolated from blood and invasion was assessed using peritoneal fluid from endometriosis patients and controls as a chemoattractant. Results: Regardless of peritoneal fluid source a > 10-fold change was seen in monocyte invasion with endometriotic monocytes. Conclusion: Peripheral blood monocytes from women with endometriosis are more invasive than those from other women. This is true when compared to both surgical and nonsurgical controls.

Authors and Affiliations

C. E. Bedient, D. Rodriguez, N. Sidell, C. Roberts, S. C. Schutte

Keywords

Related Articles

Psychological epidemiology of sexual function change after conization for cervical dysplasia

Purpose of investigation: To evaluate psychological impact of sexual function change after conization for cervical dysplasia. Materials and Method: Seventy-seven sexually active women enrolled in this study. Before coniz...

Perinatal outcome of prolonged preterm premature rupture of membranes near the limit of fetal viability

Purpose of investigation: The purpose of the present study is to evaluate the perinatal outcome of expectant management for prolonged preterm premature rupture of membranes (PPROM) near the limit of fetal viability. Mate...

Is bioelectrical impedance analysis beneficial to estimate subclinical atherosclerosis in menopause? Prospective case-control study

Aim: To evaluate body composition and basal metabolic rate in premenopausal and postmenopausal women, using the bioelectrical impedance analysis method, and to investigate its relationship with carotid intima media thick...

Pelvic organ prolapse surgery after different hysterectomy methods: a population-based cohort study

Background: Pelvic floor disorders are expected to greatly increase in the coming years. Many factors have been implicated in the development of pelvic organ prolapse (POP). In the last decade, the route of hysterectomy...

Genome-wide association study of recurrent endometriosis related with ovarian cancer

Purpose: Endometriosis is a painful and chronic gynecological disease affecting approximately 10% of reproductiveage women and has an increasing rate of recurrence. However, studies of recurrent endometriosis are lacking...

Download PDF file
  • EP ID EP618505
  • DOI 10.12891/ceog4333.2019
  • Views 60
  • Downloads 0

How To Cite

C. E. Bedient, D. Rodriguez, N. Sidell, C. Roberts, S. C. Schutte (2019). Alterations in the invasive properties of peripheral blood monocytes from patients with endometriosis. Clinical and Experimental Obstetrics & Gynecology, 46(1), 60-65. https://www.europub.co.uk/articles/-A-618505