Alterations in the invasive properties of peripheral blood monocytes from patients with endometriosis
Journal Title: Clinical and Experimental Obstetrics & Gynecology - Year 2019, Vol 46, Issue 1
Abstract
Purpose of this Investigation: The primary aim of this pilot study was to determine if the increase in monocyte/macrophage number in the peritoneal cavity of women with endometriosis is due to differences in peritoneal fluid signaling content (e.g. cytokine levels) or inherent differences in monocyte migration in response to those signals. Materials and Methods: Peripheral blood and peritoneal fluid samples were collected from endometriosis and surgical control patients at the time of surgery. Peripheral blood was also collected from a group of healthy ‘non-surgical control’ patients in an internal medicine clinic. Monocytes were isolated from blood and invasion was assessed using peritoneal fluid from endometriosis patients and controls as a chemoattractant. Results: Regardless of peritoneal fluid source a > 10-fold change was seen in monocyte invasion with endometriotic monocytes. Conclusion: Peripheral blood monocytes from women with endometriosis are more invasive than those from other women. This is true when compared to both surgical and nonsurgical controls.
Authors and Affiliations
C. E. Bedient, D. Rodriguez, N. Sidell, C. Roberts, S. C. Schutte
Keywords
Related Articles
- EP ID EP618505
- DOI 10.12891/ceog4333.2019
- Views 61
- Downloads 0
Shifting the paradigm to an obstetric humanized care: the disparities at a tertiary care hospital in the midwest of Brazil
Objectives: This study intended to evaluate the overuse of episiotomy as a routine practice at a public referral regional hospital and the changes promoted by the widespread concept of obstetric violence. Materials and M...
Diffuse leiomyomatosis of the cervix: a rare tumor in a rare location. A first report and literature analysis
Objective: Diffuse uterine leiomyomatosis (DUL) is rare and almost occurs in the corpus uteri without involving the cervix. Here the authors report a patient with DUL only involving the cervix. Case Report: A 42-year-old...
Breast changes in pregnancy and lactation observed by ultrasonography
Purpose of Investigation: To assess the ultrasound aspects of breasts and laser Doppler flow measurements of the internal mammary arteries (IMA) in pregnant, lactating, and non-pregnant (control) women. Materials and Met...
The effects of vaginal lubricants on the human vagina: an in vitro analysis
Purpose: Vaginal lubricants are widely used by women to resolve intercourse difficulties or as performance enhancers. However, little information is available regarding the safety of over-the-counter (OTC) lubricants. Th...
Anti-N-methyl-D-aspartate receptor encephalitis associated with a tiny ovarian teratoma diagnosed by exploratory laparoscopy: report of two cases
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is the most common form of paraneoplastic encephalitis that is associated with teratomas. Because removal of the tumor leads to better clinical outcomes, determining...