Ameliorative Effect of Aqueous Leaf Extract of Tectona Gondis on Egg Yolk Induced Heart and Blood Vessels Damage in Adult Wistar Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
The aim of this study was to determine the effect of aqueous extract of Tectona gondis leaf on egg yolk induced heart and blood vessel toxicity in adult wistar rats. A total of 35 (thirty five) adult wistar rats weighing between 200 g to 270 g were divided into 5 groups of seven rats per group. Group A rats were placed on normal diet only while Group B rats received 300 mg/ kg body weight / day (BWT/D) of egg yolk. Group C rats received 300mg / kg BWT/D of Tectona gondis leaf. Group D rats received 300 mg/ kg BWT/D of egg yolk and 300mg / kg BWT/D of T. gondis leaf Group E rats received 300 mg/ kg BWT/D of egg yolk and 500mg / kg BWT/D of T. gondis leaf and all the dosage were given for 30 days via orogastric administration. The biochemical result revealed that group B showed marked increase in the level of the serum SOD, CAT, cholesterol when compared with the other groups. Histologically, group B showed asevere vascular obstruction and mild perivascular infiltrates of chronic inflammatory cells, while group A,C,D and E revealed normal bundles of myocardial fibers and coronary artery. It can then be concluded that theaqueous leaf extract of T. gondis was able to reverse the vascular obstruction of the coronary artery caused by the egg yolk.
Authors and Affiliations
EHIMIGBAI, Agbonluai Richard . O1, MIEHWEE, Goodluck . O. , EHI-OMOSUN, Mabel1
Keywords
Related Articles
- EP ID EP386763
- DOI 10.9790/3008-110602889
- Views 77
- Downloads 0
Factors Affecting Biodegradation of the Organophosphorus Insecticide Diazinon by Bacterial Mono-Culture of Bacillus Sefensis 7, Isolated From the Rhizosphere of Date Palm Tree
Due to widespread use pesticides for crop protection, they are considered as contaminants in the, environmental matrices such soil which are exposed to large quantities. Three isolates from soil samples using enrichment...
A Study of Anti-inflammatory effect of Heparin and Enoxaparin on Experimentally Induced acute Inflammation in Albino Rats.
Objective: To evaluate and compare anti-inflammatory effect of Heparin and Enoxaparin with the standard drug Diclofenac sodium. Methodology: Rat paw edema induced by carrageenan was the experimental model. Albino rats we...
Isolation, Characterization and Biological Activities of Antibacterial Antibiotics Produced by Streptomycesalbus Dsm 40313
This research was carried out in the search for bioactive substances from Streptomyces that demonstrated inhibitory effect against some pathogenic bacteria. Twelve Streptomyces strains were isolated from soil samples col...
Incidence of Dengue in and around Kannur, Kerala
Dengue infection is an emerging disease and is a major health problem in our country. Globally the incidence of dengue has increased in the recent years. The WHO estimates that presently about two fifths of the world pop...
Cysteine Proteases from Carica papaya: An important enzyme group of many industrial applications
Cysteine proteases (Thiol Proteases) are specific group of proteases which carry nucleophilic cysteine thiol in their structure. They are usually obtained from different tropical and subtropical fruits such as papaya, ki...