Ameliorative Effect of Menthaspicata on Dichlorvos-Induced Oxidative Stress in the Rat Brain
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 4
Abstract
Abstract:The present study was carried out to evaluate the protective role of aqueous extract of Menthaspicata (MSE) leaf on dichlorvos (DDVP) induced oxidative stress in rat brain. Male rats were divided into 4 groups, the first group served as control (C). Group (E1) received 5.33mg/Kg BW of DDVP and group (E2) received 5.33mg/Kg BW of DDVP with MSE (100.0 mg/kg) and the group (E3) received MSE (100.0 mg/kg). Rats under all the groups were treated with their respective constituents for 30 days. The results suggested that rats under E1 suffered from significant (p<0.01) decline in the activity of superoxide dismutase, catalase, glutathione peroxidase with a significant elevation in the levels of malondialdehyde of their brain. Histological changes were also found to be prominent in the brain of E1 group as compared to others. Rats under E2 showed recuperation tendencies which were evidenced by partial restoration of antioxidant enzyme activity and the lesser degree of damage in histological aspect as compared to E1. No significant changes were observed in either biochemical constituents or histological aspects of rats under E3. The current study suggests that DDVP can cause oxidative damage and brain injury in male rats and co-administration of MSE with the selected dose partially attenuates the toxic effect caused by DDVP. Keywords: Menthaspicata, Brain, Dichlorvos, Oxidative stress and Xenobiotics.
Authors and Affiliations
David M
Keywords
Related Articles
- EP ID EP397464
- DOI -
- Views 90
- Downloads 0
Analysis of Matrix Metalloproteinases 13(MMP-13) non-synonymous Single Nucleotide Variants (nsSNVs) in Osteoarthritis and Prediction of Druggable Binding Sites Using COSMIC
Abstract:Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss and damage of articular cartilage. Increased collagenase activity has a direct impact in the cleavage of type II collagen in...
A Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Ethinylestradiol and Drospirenone in Dosage Forms
Abstract:A combination of ethinylestradiol and drospirenone is used as an oral contraceptive and also for the treatment of premenstrual dysphoric disorders, acne and hirsutism. In this study, a derivative spectrophotomet...
Evaluation of Anti-Inflammatory and Antioxidant Activities of Ethanolic Extract of Stems of Phragmantheracapitata (Sprengel) S Balle (Loranthaceae) Collected on PsidiumguajavaL. in Cameroon
Abstract: The objective of this study was to evaluate the anti-inflammatory and antioxidant activities of Phragmantheracapitata stems widely used by traditional healers. Acute toxicity according to the OECD Guideline 423...
Task Shifting: A Need for Current Health Care System
Abstract: World is facing a crisis in human health resources due to a critical shortage of health workers. Despite of many trained health care professionals our health care system is struggling to provide optimum servic...
Phytochemical Screening and in VitroAntidiabetic Activity of PlumeriaAcuminata Leaves
Abstract:The present study was carried out to evaluate the preliminary phytochemical screening and in vitroantidiabetic activity of Plumeriaacuminataleaves. The leaves of Plumeriaacuminatawas extracted with different sol...