An ecological and multi valuable raw material for obtaining effective calcium preparations.
Journal Title: IOSR Journal of Biotechnology and Biochemistry (IOSR-JBB - Year 2019, Vol 5, Issue 1
Abstract
Nine tablet formulations containing calcium salts: citrate, fumarate, gluconate were prepared. Preparations containing calcium salts were made using a modified natural source of calcium, which are the chicken eggsshells. Calcium amount, moisture, friability of tablets and disintegration time were determined in the formulations. The influence of the amount and type of calcium salt (citrate, fumarate), the amount of potato starch and inulin on disintegration time and half-release of calcium from tablets (t50%) was determined using the method of analysis of variance. Obtained results were compared to variant 9 containing calcium gluconate (reference). It was found that the amount and type of calcium salt (citrate, fumarate), starch and inulin amount are significant for the disintegration time of tablets. The disintegration time of tablets containing calcium fumarate is about 5 times longer compared to tablets with calcium citrate. Increasing the content of calcium citrate and inulin prolonges the disintegration time of tablets, and increasing of calcium fumarate and potato starch shortens the disintegration time. A significant effect of the composition of the tablet mass on the dynamics of calcium release from tablets has been demonstrated. Increasing the content of calcium citrate and inulin in tablets is slowing down the release rate of calcium from tablets, and increasing of fumarate and starch enhance the release rate.
Authors and Affiliations
Wioletta Siemiradzka, Barbara Dolińska, Florian Ryszka
Keywords
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- EP ID EP444625
- DOI 10.9790/264X-0501015057.
- Views 145
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