An Evaluation of Effect of Flaxseed Oil (N-3 Fatty Acid) Treatment on Lipid Parameters and Its Tolerability in Dyslipidemic Patients
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 1
Abstract
To evaluate the effect of flaxseed oil treatment on lipid parameters and to assess tolerability of the same in dyslipidemic patients. An interventional, prospective study was conducted on outpatients of either gender in the age group of 18-60 years. A total of 120 patients, newly diagnosed to be suffering from dyslipidemia, were enrolled in the study. Patients were randomly divided into two groups, namely placebo group and test group with 60 patients in each group. Both groups were advised dietary fat restriction for one month (Phase I), followed by administration of 2-soft gelatin capsule-BD of liquid paraffin (1 ml) in placebo group and 2-soft gelatin capsule-BD of flaxseed oil (150 mg) in test group for a period of six weeks along with dietary restriction phase-II. Lipid profile, Fasting blood sugar (FBS), Bleeding time (BT), Clotting time (CT), Prothrombin time (PT), Renal function test (RFT) and liver function tests (LFT) were recorded at base line, at the end of Phase I (dietary restriction) and Phase II (placebo and test drug treatment). A significant lowering of total cholesterol (TC), LDL, TG and VLDL and an increase in HDL values as compared to baseline was observed in both groups after phase I. At the end of phase II treatment, further improvement in these parameters was observed in test group (flaxseed oil treatment) but not in the placebo group. No adverse impact was noted FBS, LFT, RFT, BT, CT and PT in both groups. Adverse events were comparable and resolved without a need of stoppage of drug in both groups. To conclude dietary restriction and flaxseed oil treatment reduced TC, LDL, VLDL and TG and increased HDL in patients of dyslipidemia without any adverse effect on blood parameters, liver and renal function during a 6 week study. Long term studies are recommended to evaluate the anti-dyslipidemic effects and safety of flaxseed oil in a larger population.
Authors and Affiliations
D. J. Vyas
Keywords
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