AN INSTITUTIONAL STUDY TO EVALUATE THE EFFICACY AND TOXICITY OF REIRRADIATION USING CONVENTIONAL RADIOTHERAPY FOR RECURRENT MALIGNANT DISEASE

Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 3

Abstract

BACKGROUND Locoregional failure is the most frequent pattern of failure in various cancer patients despite intensified treatment and it leads to death in most of the patients. Traditionally, surgery as salvage therapy for locoregional recurrence provides the greatest probability of cure; unfortunately, the vast majority of locoregional recurrent cases are unresectable. Although chemotherapy has been the standard of care for patients who are not candidates for surgery, the response rates are limited. Reirradiation is a potentially curative or best palliative treatment option for some patients with unresectable disease. This study reported our experience of reirradiation alone or concurrent chemoradiotherapy in recurrent malignant condition. MATERIALS AND METHODS We reviewed 26 consecutive patients with a diagnosis of locoregional recurrences (LRR) of Head and Neck, Cervix, Urinary Bladder, CNS carcinoma treated with a second course of radiotherapy. The main outcome measures were local control, overall survival, and complications. RESULTS Efficacy and toxicity were scored by looking at the reduction in tumour size, pain and bleeding. Reduction in tumour size and pain reduction after reirradiation were seen in 100% and 95% of the patients respectively. In 95% of the cervical carcinoma patients there was a reduction in bleeding. The 1-year local control rate for the whole group was 64%. Symptomatic response was observed in 96% of the patients. No grades 5, 4 and 3 acute and late toxicity was observed. CONCLUSION Continuous course reirradiation in patients with LRR in various carcinoma is feasible with acceptable toxicity. With current encouraging rates of local control and overall survival, this option should be discussed with patients who have few alternative therapeutic options.

Authors and Affiliations

Sudhir Katariya, Manish Verma, Arpit Jain, Vinay Shivhare, Allwin George, Minaal Iyer, Ashish Malviya, Abhishek Pratap Singh

Keywords

Related Articles

 MAGNETIC RESONANCE IMAGING OF THE INTERNALLY DERANGED KNEE JOINT - A PROSPECTIVE STUDY

[b] BACKGROUND & OBJECTIVE[/b]: Trauma to knee joint is a significant cause of morbidity in the young, active individuals and athletes. An accurate diagnosis regarding the type and extent of injuries is esse...

HETEROTOPIC PREGNANCY AFTER SPONTANEOUS CONCEPTION- A RARE ENTITY

PRESENTATION OF CASE We report a rare case of Heterotopic pregnancy in a natural conception cycle, where a clinically stable patient with low risk factors which was picked up on USG. This case report emphasises the impor...

VITAMIN D3 LEVELS IN TWO DIFFERENT ETHNIC POPULATIONS- A BIRD’S EYE VIEW ON SOCIOCULTURAL INFLUENCES

BACKGROUND The prevalence of Vitamin D deficiency has steadily risen in last few years. Environmental factors like temperate climate, indoor lifestyle, diet prejudice as well as human behavioural patterns among ethnic gr...

 CLINICAL AND BACTERIOLOGICAL STUDY OF ACUTE DIARRHOEA IN CHILDREN

[b] OBJECTIVES[/b]: To know the hospital prevalence and clinical features of acute diarrhoea and describe the common bacterial pathogens isolated in these cases of diarrhoea in children. [b]MATERIALS AND METHODS...

A COMPARATIVE EVALUATION OF FLUID PRELOADING VS. CO-LOADING ON MATERNAL HAEMODYNAMICS AND NEONATAL OUTCOME FOR THE PARTURIENTS UNDERGOING EMERGENCY CAESAREAN DELIVERY- A PROSPECTIVE, RANDOMISED, DOUBLE-BLIND, PARALLEL GROUP STUDY

BACKGROUND Emergency caesarean section (CS) is very often done under spinal anaesthesia unless contraindicated. This neuraxial block results in hypotension caused by pharmacological sympathectomy. This effect can lead to...

Download PDF file
  • EP ID EP553110
  • DOI 10.14260/jemds/2019/38
  • Views 73
  • Downloads 0

How To Cite

Sudhir Katariya, Manish Verma, Arpit Jain, Vinay Shivhare, Allwin George, Minaal Iyer, Ashish Malviya, Abhishek Pratap Singh (2019). AN INSTITUTIONAL STUDY TO EVALUATE THE EFFICACY AND TOXICITY OF REIRRADIATION USING CONVENTIONAL RADIOTHERAPY FOR RECURRENT MALIGNANT DISEASE. Journal of Evolution of Medical and Dental Sciences, 8(3), 174-176. https://www.europub.co.uk/articles/-A-553110