An Interventional Study to Evaluate the Efficacy of Topical Ivermectin in the Management of Uncomplicated Scabies
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 2
Abstract
Introduction: Scabies is a common itching dermatoses caused by Sarcoptes scabiei. It presents with scabies rash and nocturnal itching. Though oral ivermectin has been found to be a safe and effective alternative to other scabicides, there is very little data on topical ivermectin preparations in management of uncomplicated scabies. So present study was conducted to evaluate the efficacy of topical ivermectin formulation in the management of human scabies. Material and Methods: Fifty patients of uncomplicated scabies were enrolled in an an open-labelled prospective interventional study and were prescribed 0.5% topical ivermectin cream, two applications, one week apart. Scabies was categorized as mild (<10 lesions), moderate (11-49 lesions) or severe scabies (>50 lesions). Pruritus severity was assessed on the Visual Analogue Scale as mild (1-3cm), moderate (4-6cm) or severe (7-10cm). The patients were examined at baseline and followed up at the end of 1st, 2nd and 4th week and scabies severity and pruritus severity was noted at each visit. Wilcoxon-Signed Rank Test was applied as test of significance. P value < 0.05 was cut off. Results: Majority of the patients (76%) had moderate to severe scabies and pruritus was severe in 36% patients at baseline. After one application, there was decrease in scabies severity (P<0.001) and pruritus severity (P<0.001), but only one patient was cured. After the second application, 98% patients had no scabeitic lesions (P<0.001) while 80% were pruritus free (P<0.001). Conclusions: Topical ivermectin cream (0.5%), two applications, one week apart is effective in treatment of uncomplicated scabies.
Authors and Affiliations
Swetabh Verma, Marya Ahsan, H. K. Singh, P. K. Rathore
Keywords
Related Articles
- EP ID EP429938
- DOI -
- Views 120
- Downloads 0
Empyema Thoracis with Breast Abscess and Surgical Blade in Thorax
Introduction: ICD placement in fatty patients and, females with heavy breasts is difficult Here we describe a case of empyema thoracis with breast abscess in whom surgical blade was slipped into thoracic cavity during IC...
Utility of Fine Needle Aspiration Cytology in the Diagnosis of Extrapulmonary Tuberculosis: Study at a Tertiary Care Centre of Kashmir Valley
Introduction: Tuberculosis(TB) can involve any organ system of our body. While pulmonary TB is most common presentation, extra pulmonary tuberculosis is also equally important problem. Cervical lymph nodes are the common...
Frontal Facial Morphological Changes related to Twin Block Appliance using Posteroanterior Cephalogram - A Prospective Comparative Study
Introduction: The class II malocclusion is one of the most common orthodontic problems and is seen in nearly 1/3rd of the population. Study was done to assess the treatment induced dentoskeletal cephalometric changes in...
Comparative Study of Intrathecal Bupivacaine with Bupivacaine Plus Clonidine in Lower Limb Surgeries
Introduction: Initially adjuvants like clonidine was added to find out whether the addition of clonidine to bupivacaine changes its efficacy and to find out any change in quality of sensory and motor block and also to fi...
Observation on Symptoms Persisting after Laparoscopic Cholecystectomy
Introduction: Laparoscopic cholecystectomy which is most widely practiced for symptomatic gallstones has gained tremendous popularity over the last three decades. A substantial amount of patients presenting with persisti...