An Open Label Prospective Study to Evaluate the Efficacy of Entecavir in HBeAg Positive Treatment Naive Chronic Hepatitis –B Patients in A Tertiary Care Centre in Eastern India
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 6
Abstract
Background: Entecavir is a nucleoside analogue drug that has selective anti-hepatitis B virus (HBV) activity. It is indicated for the treatment of chronic hepatitis B virus infection in adults with evidence of active viral replication, persistent elevations in serum aminotransferase and histologically active disease. We conducted a study to evaluate the efficacy of entecavir (ETV) in hepatitis Beantigen (HBeAg) positive- chronic hepatitis B (CHB) treatment naive Indian patients in real life scenario. Method: This is a single center open label prospective observational study to evaluate the efficacy of Entecavir in chronic hepatitis B patients. A total of 140 patients were enrolled in the study from January 2015 to December 2016. Parameters were evaluated at baseline and at 12, 24 and 40 weeks of the treatment, Efficacy of entecavir was assessed by evaluating hepatitis B virus DNA (HBV DNA), serum alanine aminotransferase (ALT) and sero-conversion. Result: The mean HBV DNA at baseline was 5.99 log [on a base-10 scale] IU/mL which decreased to 2.12 log IU/mL at the end of 40 weeks. Thus there was a mean change of 3.87 log IU/ml which was statistically significant (P<0.0001). Out of 140 HBeAg positive subjects, 50 (35.71 %) had become negative at the end of 40 weeks. Only 10.71% of the patients had normal ALT (<40IU/l) values in the beginning which increased to 100% at the end of 40 weeks. Conclusion: Entecavir significantly improves virological, biochemical and serological markers in HBeAg positive treatment naïve chronic hepatitis B patients.
Authors and Affiliations
Jayanta Kumar Panda
Keywords
Related Articles
- EP ID EP285648
- DOI -
- Views 76
- Downloads 0
Case Control Study of Lifestyle and Behavioral Risk Factors of Coronary Artery Disease in Tertiary Care Hospital
In India 53% of all deaths was due to non-communicable diseases and 28% deaths were due to cardiovascular diseases like coronary artery disease (CAD). This epidemic of non-communicable diseases is due to steep rise of li...
Analysis of Blood Urea and Serum Creatinine in Controls and Type-2 Diabetic Patients
Diabetes mellitus is a chronic metabolic disorder that can lead to cardiovascular, renal, neurologic and retinal complications. Type 2 diabetes mellitus has quickly become a global health problem due to rapidly increasin...
Microbiological Study of Chronic Supperative Otitis Media in Indian Population
A total 201 discharge from ear (pus) were collected from different patients. The study was carried out in patients and out patients in the hospital. The specific objective of this study was to do microbiological study of...
An observational analysis regarding factors contributing to tobacco usage among patients diagnosed with tobacco associated malignancies: a study from the Kumaon region of India
Aim: Despite decades of efforts by the government of India toward tobacco regulation and raising awareness of tobacco induced carcinogenesis, there is a very high incidence of tobacco induced malignancy in Indian subcont...
Impact of 4 weeks Yoga training on Anxiety level and Guna in Substance Abuser
The objective of the study was to evaluate the effect of yoga on anxiety and guna of substance abusers. 28 drug abused men, from a de-addiction centers, with the mean of age29.04±8.36years participated in the randomized...