An Open Label Prospective Study to Evaluate the Efficacy of Entecavir in HBeAg Positive Treatment Naive Chronic Hepatitis –B Patients in A Tertiary Care Centre in Eastern India
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 6
Abstract
Background: Entecavir is a nucleoside analogue drug that has selective anti-hepatitis B virus (HBV) activity. It is indicated for the treatment of chronic hepatitis B virus infection in adults with evidence of active viral replication, persistent elevations in serum aminotransferase and histologically active disease. We conducted a study to evaluate the efficacy of entecavir (ETV) in hepatitis Beantigen (HBeAg) positive- chronic hepatitis B (CHB) treatment naive Indian patients in real life scenario. Method: This is a single center open label prospective observational study to evaluate the efficacy of Entecavir in chronic hepatitis B patients. A total of 140 patients were enrolled in the study from January 2015 to December 2016. Parameters were evaluated at baseline and at 12, 24 and 40 weeks of the treatment, Efficacy of entecavir was assessed by evaluating hepatitis B virus DNA (HBV DNA), serum alanine aminotransferase (ALT) and sero-conversion. Result: The mean HBV DNA at baseline was 5.99 log [on a base-10 scale] IU/mL which decreased to 2.12 log IU/mL at the end of 40 weeks. Thus there was a mean change of 3.87 log IU/ml which was statistically significant (P<0.0001). Out of 140 HBeAg positive subjects, 50 (35.71 %) had become negative at the end of 40 weeks. Only 10.71% of the patients had normal ALT (<40IU/l) values in the beginning which increased to 100% at the end of 40 weeks. Conclusion: Entecavir significantly improves virological, biochemical and serological markers in HBeAg positive treatment naïve chronic hepatitis B patients.
Authors and Affiliations
Jayanta Kumar Panda
Prospective Study to find out whether Continuous Curvilinear Capsulorrhexis is mandatory to achieve a Good Result in Phacoemulsification
Aim of this study is to find out whether it is mandatory to do Curvilinear continuous capsulorhexis(CCC) to achieve a good result in phacoemulsification. Materials and methods consisted of a prospective, randomised study...
Mycobacterium tuberculosis resistance to Isoniazid and Rifampicin in a HIV- 1 endemic population in western Kenya in 2012-2014
Background: Mono-resistant and multi-drug resistant tuberculosis (MDR-TB) has been enhanced by delays in the identification of resistant strains. However, resistance gene patterns and the extent of monoresistant TB and M...
Effect of Physical Stress on Heart Rate Variability (HRV) in Subjects of Type 'A' and Type 'B' Personality: A Comparative Interventional Study
Background: Stress is an individual’s inability to cope up with the altered situation. The stress may be mental or physical or both. Stress up to an optimal level is necessary to achieve the target but prolonged stress m...
Autoamputation of Penis Following A Fournier’s Gangrene – A Rare Occurrence
Fournier’s gangrene is a type of polymicrobial necrotizing fasciitis involving perineal, perianal and urogenital region, especially the scrotum but rarely involves the penis. The penis is relatively spared of this life t...
Thyroid Dysfunction in End Stage Renal Disease
The study is aimed to look at the prevalence of thyroid disorder in end stage renal disease. The data was collected from the patients reported to dialysis unit, OPD and wards. During the duration of 1 year, 30 patients w...