An Overview on Anti-Chronic Myelogenous Leukaemia efficacy of Spergulin A
Journal Title: International Journal of Innovative Research in Computer Science and Technology - Year 2022, Vol 10, Issue 2
Abstract
One of the main causes of mortality in the 21st century has been cancer. Even among cancer, chronic myelogenous leukaemia (CML) is one of the main causes for cancer associated death. Despite its ubiquity the breadth of therapy is restricted by its high cost and lack of effectiveness. Spergulin –A, a saponin which is a triterpenoid, isolated from an n-butanol fraction of the flowering plant Glinus oppositifolius has been reported previously for its anti-leishmanial activity. In this study, Spergulin-A was isolated from Glinus oppositifolius and its Identification and structural confirmation was achieved by NMR, after which it was tested for its anti-CML action. As per the present results, Spergulin-A was found to cause growth inhibition and trigger apoptosis in K562, a cell line of chronic myelogenous leukaemia, origin. Moreover, Spergulin-A has demonstrated no detrimental effects against normal cell lines. Based on these results, it can be reasonably concluded that Spergulin-A may be used as an anti-CML agent.
Authors and Affiliations
Kausar Fatima
An Analysis of Vehicle Diagnostic and Tracking Tool Using Android
The use of mobile phones while driving is one the most dangerous and widely seen causes of fatal accidents .The main aim of our project is to develop a system to keep a track on the person driving the vehicle and ensurin...
The Effect of Different Physical Treatment and Stimulation Temperature on OSL Decay Curve of Synthetic Quartz Material
Researchers reported, in natural quartz probability of re-trapping of electrons by shallow TL traps gets reduced for Optically Stimulated Luminescence (OSL) at around 160 0C and usual shape of OSL decay curve is obtained...
An Enhanced AODV Routing Protocol to detect and isolate selfish nodes in Manets
The fact that security is a critical problem when implementing mobile ad hoc networks (MANETs) is widely acknowledged. One of the different kinds of misbehaviour a node may exhibit is selfishness. A selfish node is a nod...
A Black Hole Activity Fundamental Plane
The characteristics of the disc–jet relationship in star weight and active galactic nuclei is studied using compact emissions in the Anti - anti and radio bands. We put together a group of 100 cosmic rays nuclei containi...
A Review Study on Chillies as Food
Chilies are made up of nonvolatile ether soluble extractives from dried ripe Capsicum fruits. It's an annum line. var: minimum, family member Chili Solanaceae is an important crop in soup preparation. It has a minimum of...