ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF VITEX NEGUNDO (LEAVES) EXTRACT
Journal Title: International Journal of Pharmacognosy - Year 2014, Vol 1, Issue 5
Abstract
Aims: Analgesic and anti-inflammatory effects of Vitex negundo leaves extract (VNE) were evaluated in the animal models. The VNE was evaluated for the phytochemical analysis. Settings and Design: Factorial design was used for the experimental models. Methods and Material: The analgesic effects at graded doses of VNE (40-320 mg/kg, p.o.) were evaluated in mice against acetic acid-induced writhing (chemically induced pain) and hot-plate method (thermally induced pain). The analgesia produced by VNE was compared with the standard analgesics diclofenac sodium (DIS, 5 mg/kg, p.o.) and pentazocine (PTZ, 5 mg/kg, p.o.). Acute anti-inflammatory activity of VNE was also analyzed using carrageenan-induced rat paw edema model at the doses 40, 80 and 160 mg/kg i.p., using diclofenac sodium (5 mg/kg, i.p.) as standard. Statistical Analysis Used: ANOVA was applied followed my Tukey's post hoc test for comparison between the group's Results: In comparison to control group VNE showed highly significant, dose-dependent analgesic activity against chemically as well as thermally induced pain models (P<0.05). In comparison to control, VNE at the employed doses produced marked acute anti-inflammatory activity in rats (P<0.05). Conclusion: The results suggest that the aqueous extract of Vitex negundo has significant analgesic and anti-inflammatory potential as reflected by the parameters investigated. Further investigations are however necessary to explore mechanism(s) of action involved in these pharmacological activities.
Authors and Affiliations
P. S. Mishra et al.
Keywords
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