Analgesic, pro and anti-inflammatory activities of Desplatsia dewevrei; Cytokine gene expression using Wistar rats and mice
Journal Title: UNKNOWN - Year 2018, Vol 7, Issue 2
Abstract
Objective: Painkilling potential of Desplatsia dewevrei methanol leaf extract was examined using the acetic acid-induced writhing and hot-plate tests. Materials & Methods: Acute anti-inflammatory effect was studied using xylene-induced ear edema and carrageenan induced paw edema models. Gene expression using RT-PCR method was used to query TNF-α, resistin and adiponectin in Wistar rats after a 3-day administration of Desplatsia dewevrei. Results: Desplatsia dewevrei extract significantly (p<0.05) decreased the number of writhes in mice at 30 mg/kg when compared to the control and Aspirin. In the hot plate induced pain test, 10 mg/kg of extract triggered comparable analgesic effect as morphine up to 2 hrs after drug administration. There was significant decrease (p<0.05) in xylene-induced ear oedema at 10 and 30 mg/kg doses of the extract with 80% and 30% when compared to control and dexamethasone. For Carrageenan-induced paw oedema in rats, 30 mg/kg elicited equal effect as indomethacin at 10 mg/kg respectively. The downward regulation/expression of TNF-α, resistin and adiponectin in contrast with control and the expression of beta-actin further indicates that Desplatsia dewevrei has both pro and anti-inflammatory activities. Conclusion: Desplatsia dewevrei methanol leaf extract is anti-inflammatory and elicits both peripherally and centrally analgesic effect.
Authors and Affiliations
Oghale Ovuakporie-Uvo, MacDonald Idu, Philip Obarisiagbon, Callistus Abode
Keywords
Related Articles
- EP ID EP588775
- DOI -
- Views 79
- Downloads 0
Chemical constituents and pharmacological action of Ocimum sanctum (Indian holy basil-Tulsi)
The plant of Oscimum sanctum commonly known as “Tulsi”, belong to Lamiaceae family. It is an erect, much branched, fragrant and erected plant attaining a height of about 20-50 cm. Different parts of the plant are used in...
Plants used in Bandjoun village (La'Djo) to cure infectious diseases: An ethnopharmacology survey and in-vitro Time-Kill Assessment of some of them against Escherichia coli
An ethnopharmacology survey concerning the medicinal plants used in Bandjoun village (La'Djo) to cure infectious diseases was carried out in three districts of this village. The survey led to the identification of 79 med...
Effect of Seabuckthorn leaves on Antioxidant and Microsomal Enzymes in poultry birds
In vivo studies on broiler birds were carried out to evaluate effect of aflatoxin and seabuckthorn leaves on microsomal enzyme system, antioxidant enzymes and biochemical parameters i.e. serum triglyceride, total plasma...
Pharmacognostical and Phytochemical Evaluation of Gandhakadi Yoga
Thalassemia is one of the most challenging form of Haematological disorders. Gandhakadi Yoga is an Ayurvedic medicine comprising of SHUDDHA GANDHAKA (Sulphur), VIDANGA (Embelia ribes Burm.f.), AGASTYA PATRA (Sesbaniya gr...
In-vitro antimicrobial activity of ethyl acetate extract of two common edible mushrooms
Ethyl acetate extracts of the reishi (Ganoderma lucidum) and oyster (Pleurotus ostreatus) mushrooms were tested for their in vitro growth inhibitory activity against a panel of microorganisms of reference strains. Antimi...