Analgesic, pro and anti-inflammatory activities of Desplatsia dewevrei; Cytokine gene expression using Wistar rats and mice

Journal Title: UNKNOWN - Year 2018, Vol 7, Issue 2

Abstract

Objective: Painkilling potential of Desplatsia dewevrei methanol leaf extract was examined using the acetic acid-induced writhing and hot-plate tests. Materials & Methods: Acute anti-inflammatory effect was studied using xylene-induced ear edema and carrageenan induced paw edema models. Gene expression using RT-PCR method was used to query TNF-α, resistin and adiponectin in Wistar rats after a 3-day administration of Desplatsia dewevrei. Results: Desplatsia dewevrei extract significantly (p<0.05) decreased the number of writhes in mice at 30 mg/kg when compared to the control and Aspirin. In the hot plate induced pain test, 10 mg/kg of extract triggered comparable analgesic effect as morphine up to 2 hrs after drug administration. There was significant decrease (p<0.05) in xylene-induced ear oedema at 10 and 30 mg/kg doses of the extract with 80% and 30% when compared to control and dexamethasone. For Carrageenan-induced paw oedema in rats, 30 mg/kg elicited equal effect as indomethacin at 10 mg/kg respectively. The downward regulation/expression of TNF-α, resistin and adiponectin in contrast with control and the expression of beta-actin further indicates that Desplatsia dewevrei has both pro and anti-inflammatory activities. Conclusion: Desplatsia dewevrei methanol leaf extract is anti-inflammatory and elicits both peripherally and centrally analgesic effect.

Authors and Affiliations

Oghale Ovuakporie-Uvo, MacDonald Idu, Philip Obarisiagbon, Callistus Abode

Keywords

Related Articles

Ethnobotanic and toxicological study of some medecinal plants used in treatment of diabetes

Aim: These ethnobotanical investigations within drug sellers of medicinal plants in Côte d'Ivoire (CI) were performed in order to contribute to a better knowledge of plants with antidiabetic effect. They were carried in...

Ethnobotany of medicinal plants used by the Zafimaniry clan in Madagascar

During an ethnobotanical survey conducted among the Zafimaniry clan in the Amoron'i Mania region of Madagascar, 164 medicinal plants species from 138 genera and 73 families are recorded to be used by local people to trea...

Ethnomedicinal, pharmacological and antimicrobial aspects of Moringa oleifera Lam.: A review

The inclusive information is provided in present review on traditional uses, antimicrobial activity and pharmacology of Moringa oleifera Lam. It is commonly known as ‘drumstick tree’. M. oleifera is alternative tonic, as...

Preclinical evaluation of antidiabetic activity of poly herbal plant extract in streptozotocin induced diabetic rats

Objective: To study and compare the effect of Poly herbal plant extract (PHPE) with Glibenclamide (GL) on various parameters in Streptozotocin (STZ) induced diabetic rats. Methods: Diabetes was induced by combining High...

Hepatoprotective potentials of Picralima nitida against in vivo carbon tetrachloride-mediated hepatotoxicity

This research aimed at investigating the in vivo Carbon tetrachloride (CCl4)-mediated hepatotoxicity of methanolic seed extract of Picralima nitida (P. nitida) using Wistar rats. Twenty five (25) rats randomly selected i...

Download PDF file
  • EP ID EP588775
  • DOI -
  • Views 80
  • Downloads 0

How To Cite

Oghale Ovuakporie-Uvo, MacDonald Idu, Philip Obarisiagbon, Callistus Abode (2018). Analgesic, pro and anti-inflammatory activities of Desplatsia dewevrei; Cytokine gene expression using Wistar rats and mice. UNKNOWN, 7(2), 185-190. https://www.europub.co.uk/articles/-A-588775