ANALYSIS OF ABO GROUP DISCREPANCIES IN A TERTIARY CARE CENTRE SOUTH INDIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 79
Abstract
BACKGROUND ABO system remains the most important blood group system in transfusion and organ transplantation medicine. ABO typing and ABO incompatibility testing remain the foundation of all pretransfusion testing. An inverse reciprocal relationship exists between the presence of A and B antigens on red cells and the presence of Anti-A and Anti-B or both in sera. Discrepancies in ABO grouping can be characterised by inappropriate results in either cell or serum grouping. The aim of this study is to analyse commonly occurring ABO group discrepancies in order to standardise resolving procedure and avoid delay in pretransfusion testing. MATERIALS AND METHODS Descriptive study period included from 2012 to 2016, the pretransfusion tests done by tube and gel column agglutination method. Total 28,024 blood grouping and typing tests were retrospectively evaluated in the study. RESULTS ABO blood group discrepancies were identified in 1331 cases, which is equal to 4.75% of total tests. Subgroups of A in 1089 cases (81%), Autoantibodies in 187 cases (14.5%), Alloantibodies in 33 cases (2.56%), 16 cases were typed as Bombay phenotype and 8 as H deficient probably, Para-Bombay phenotype and two cases of multiple myeloma and heparin contaminated sample causing discrepancy in cell grouping. These cases were identified during pretransfusion workup. CONCLUSION Resolving ABO and Rh grouping and typing discrepancy is crucial in pretransfusion testing and selecting proper blood and blood products in transfusion services. Most of the problems can be resolved by basic immunohaematological techniques.
Authors and Affiliations
Bonagiri Shanthi, Ravi Babu K
Keywords
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- EP ID EP268081
- DOI 10.14260/jemds/2017/1218
- Views 121
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