Analysis of disease spectrum and epidemiology of inpatients with neuroophthalmic disease from single center
Journal Title: Eye Science (Yanke Xuebao) - Year 2023, Vol 38, Issue 3
Abstract
[Objective:] To analyze the spectrum and epidemiological characteristics of neuro-ophthalmic diseases from single center, and to provide basis for guiding the diagnosis and treatment of neuro-ophthalmic diseases. [Methods:] Patients with neuro-ophthalmic diseases admitted to the neuro-ophthalmology ward of Chinese PLA General Hospital from January 1, 2010 to December 31, 2021 were enrolled. The age, gender, regional distribution and disease subtypes of all included patients were retrieved and recorded from the electronic case system. [Results:] A total of 7245 neuro-ophthalmic patients were enrolled, including 3331 males (46.0%) and 3914 females (54.0%), with a male to female ratio of 1: 1.2. The average age was (38.2±17.5) years. The 83.25% (6031/7245) were afferent nervous system diseases, 9.92% (719/7245) were efferent nervous system diseases and orbital diseases, and 6.83% (495/7245) were not classified. The analysis of disease type showed that the ratio of demyelinating optic neuritis (DON) was the highest (40.17%, 2910/7245), followed by non arteritic anterior ischemic optic neuropathy (NAION) (11.37%, 824/7245) and traumatic optic neuropathy (TON) (5.15%, 373/7245). The proportion of optic nerve atrophy with unknown causes was 7.85% (569/7245). From the perspective of age distribution, the DON and TON traumatic optic neuropathy patients were more common in 18-40 age group (the proportions were 48.63% and 44.24%, respectively), the NAION patients aged 41-60 years accounted for the highest proortion (66.14%), and the minor patients less than 18 years old accounted for the highest proportion ofhereditary optic neuropathy (48.58%). Among 2226 DON patients, the proportion of neuromyelitis optica (NMO)/neuromyelitis optica spectrum disorder (NMOSD)-optic neuritis (ON) was the highest (60.02%) and myelinoligodendrocyte glycoprotein antibody (MOG-IgG) ON was 11.68%, while multiple sclerosis (MS)-ON and chronic recurrent inflammatory optic neuropathy (CRION) were relatively low (1.8% and 2.25%, respectively). Among DON patients, the male to female ratio was 1: 3.08. In NMO/NMOSD-ON patients, the ratio of male to female was 1: 8, and that of MOG-ON was 4: 5. In atypical ON, the ratio of male was higher than that of female (1.28: 1). In DON patients, 81.79% of patients were young and middle-aged, and the proportion of minor children with MOG-ON was 41.15%. [Conclusions] DON and NAION are the two most common diseases of neuro-ophthalmic afferent system.
Authors and Affiliations
Wenhao BAI, Mingming SUN, Xintong XU, Xiyun Chen, Shihui WEI, Huanfen ZHOU
Keywords
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- EP ID EP764619
- DOI 10.12419/j.issn.1000-4432.2023.03.03
- Views 20
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