Analysis of Microbial Profiles and Their Resistance Pattern in Pleural Fluid Samples from a Tertiary Care Centre.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 2
Abstract
Background: Acute respiratory tract infection is the leading cause of morbidity and mortality. Several possible mechanisms of pleural effusion have been proposed accompanying various underlying diseases like Heart failure, Pneumonia, Pleural malignancy & Cirrhosis Liver. One of the major problems world-wide is the increase in antibiotic resistant strains of bacteria, which has proved difficult to control. Objectives: To identify the presence of lactose fermenting bacilli in pleural fluid samples with their resistance pattern along with different enzyme mechanisms responsible for resistance. Material and methods: This study was carried out in Microbiology Division of Central laboratory, SMIH, Patel nagar, Dehradun. A total number of 215 samples, over a period of 12 months from November 2016 to October 2017, were collected for the examination. Out of which, only 31 positive samples were processed to determine the etiology and antimicrobial susceptibility pattern using VITEK 2 compact system. All patients suffering from tuberculosis were excluded from the study. Results: Out of total samples, only 31 samples showed culture positivity with majority of Gram negative bacilli (23). Among Gram negative bacilli, 12 were lactose fermenters. Enterobacter spp (07/12) was the predominant isolate with high resistance for Piperacillin Tazobactum which is now the only drug left for treatment in most of the cases. Conclusion: The study was carried to find out the microbiological association of pleural effusion in nontubercular cases. Indiscriminate and overuse of broad spectrum antibiotics predisposes the affected patients to develop multi drug resistant virulent micro flora.
Authors and Affiliations
Khan Z. I. , Jauhari S. , Kataria V. K
Keywords
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- EP ID EP467050
- DOI 10.9790/0853-1802063540.
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