Analysis of risk factors for non-sentinel lymph node metastasis in patients with sentinel lymph node-negative breast cancer
Journal Title: Journal of Surgery : Concepts & Practice - Year 2024, Vol 29, Issue 5
Abstract
[Objective] To analyze the risk factors for non-sentinel lymph node (NSLN) metastasis in patients with sentinel lymph node (SLN)-negative breast cancer. [Methods] Patients with breast cancer who underwent mastectomy and SLN biopsy at our center between January 2009 and August 2024 were retrospectively included. Univariate and multivariate analyses were performed in SLN-negative populations underwent low axillary lymph node dissection to identify risk factors for NSLN metastasis. [Results] A total of 2 387 SLN-negative patients were included, including 2 288 (95.9%) without NSLN metastasis and 99 (4.1%) with NSLN metastasis. Univariate and multivariate analyses showed that lymphovascular invasion (LVI) was an independent risk factor for NSLN metastasis in SLN-negative patients (13.5% versus 3.5%; OR=4.14，95% CI: 2.27-7.56，P<0.001). Patients with multicentric breast cancer showed a trend towards higher risk of NSLN metastasis compared to other types of breast cancer (9.5% versus 4.1%; OR=2.08，95% CI： 0.90-4.81，P=0.089). [Conclusions] Patients with SLN-negative biopsy who have LVI or multicentric breast cancer are at higher risk for NSLN metastasis.
Authors and Affiliations
Fengzhe ZHANG, Yiwei TONG, Xiaosong CHEN, Kunwei SHEN
Keywords
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- EP ID EP761795
- DOI 10.16139/j.1007-9610.2024.05.08
- Views 20
- Downloads 0
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