Analysis of the effectiveness of structured cognitive rehabilitation therapy in post-stroke cognitive impairment patients in Singapore
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 4
Abstract
[Objective] Literature on cognitive prognoses in association with stroke-related and pre-stroke factors, are surprisingly meagre. Prognoses of patients with post stroke cognitive impairment (PSCI) to structured cognitive rehabilitation are not clearly understood. This study aimed to compare if the prognoses of stroke survicors after cognitive rehabilitation programme was associated with chronic cerebrovascular disease (CVD). [Methods] An eight-week non-pharmacological clinical programme was ran for patients with mild strokes to provide clinical support to stroke patients and collect longitudinal data on stroke prognoses. 149 ischemic stroke survivors (age 63.6±9.66, 64.4% males) underwent an eight-week structured group cognitive rehabilitation programme. Baseline, immediate post programme (Immediate-PP) and 6-month post programme (6-month-PP) global cognitive and quality of life outcomes were assessed by Montreal cognitive assessment (MoCA) and dementia-quality of life instrument (DemQOL). Regression analyses evaluated the influence of cognitive rehabilitation on outcomes. [Results] With every past stroke experienced by patients, they were less likely to demonstrate an improvement in MoCA score Immediate-PP ( OR=2.17, 95% CI: 0.980-4.813, P=0.056). Patients with severe white matter hyperintensities were less likely to demonstrate an improvement in MoCA scores Immediate-PP compared to Baseline ( OR=2.13, 95% CI:1.04-4.38, P=0.039). Finally, patients with microhemorrhages in the deep region were less likely to demonstrate an improvement in MoCA at 6-month-PP ( OR=19.93, 95% CI: 1.04-384, P=0.047). [Conclusions] Pre-stroke CVD is associated with poorer cognitive outcomes post cognitive rehabilitation. Our initial programme shows promising results - however further research into cognitive rehabilitation for stroke survivors with pre-stroke CVD is needed. The findings from our clinical rehabilitation programme will be useful guiding the design of a clinical trial.
Authors and Affiliations
Yijin LEOW, Chao DANG, Nagaendran KANDIAH
Keywords
Related Articles
- EP ID EP750489
- DOI 10.3969/j.issn.1002-0152.2024.04.001
- Views 76
- Downloads 0
A case of cerebral small vascular disease and hyperhomocysteinemia caused by methylenetetrahydrofolate reductase deficiency
A case of small cerebral vascular disease and moderate hyperhomocysteinemia caused by methylenetetrahydrofolate reductase gene mutation is reported. The patient was a 61-year-old man who presented with tongue stiffness a...
Mid-to-long-term quality of life and psychological status after endovascular embolization of unruptured intracranial aneurysms
[Objective] To investigate whether embolization surgery can improve mid-to-long-term outcomes related to quality of life, anxiety and depression in patients with unruptured intracranial aneurysms (UIA). [Methods] This pr...
Analysis of the association between threat and deprivation childhood traumas and dysfunctional attitudes in patients with major depressive episode
ObjectiveThis study aims to explore the associations between threat and deprivation childhood traumas and dysfunctional attitudes among patients with major depressive episode, based on the dimensional model of adversity...
Advances on inflammation induced by oral microbiota and atherosclerosis
Atherosclerosis (AS) is a leading cause of coronary heart disease, myocardial infarction and ischemic stroke. It has been demonstrated that oral microbiome may potentially affect the progression of AS. Oral microbial dis...
A case of myotonic dystrophy with white matter lesions
Myotonic dystrophy type 1 (DM1) is a rare hereditary disease characterized by myotonic and myasthenia, which can affect multiple systems throughout the body. In order to improve the understanding of the nervous system in...