Analytical Method Development and Validation for Estimation of Alpha Lipoic Acid in Bulk and Pharmaceutical Dosage Form by UV Spectrometric Method
Journal Title: Journal of Biological and chemical Chronicles - Year 2018, Vol 4, Issue 1
Abstract
A rapid, specific and economic UV spectrophotometric method has been developed to determine the alpha lipoic acid content in bulk and pharmaceutical dosage formulations. At a pre-determined absorption maxima of 334 nm, it was proved linear in the range of 100-500μg/ml, and exhibited good correlation coefficient (R2=0.998) and excellent mean recovery (99.8% to 101.60%). This method was successfully applied to the determination of alpha lipoic acid and validated statistically and by recovery studies for linearity, precision, repeatability, and reproducibility. The obtained results proved that the method can be employed for the routine analysis of alpha lipoic acid in bulks as well as in the commercial formulations.
Authors and Affiliations
Mayur Patni, Swati Rawat
Keywords
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