ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF FAROPENEM IN BULK AND PHARMACEUTICAL FORMULATION USING THE RP-HPLC METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the determination Faropenem in Bulk and pharmaceutical dosage form. The column used was Symmetry C18 (4.6 x 150mm, 5 m, Make: ODS) or equivalent in isocratic mode, with mobile phase containing phosphate buffer adjusted the pH-4.0 with orthophosphoric acid and Acetonitrile in the ratio (70:30%v/v) the flow rate was 0.9 mL/ min and eluents was monitored at 317 nm. The retention time Faropenem was 3.051 min, respectively. The linearity for Faropenem was in the range of 40-120 µg/ml respectively. The recovery of Faropenem was found to be 100.1%, respectively. The proposed method was validated and successfully applied to the estimation of Faropenem in tablet dosage form.
Authors and Affiliations
Rizwana Iffath , Vanitha Prakash, Krishna Mohan
Keywords
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