Anti-arthritic activity of leaves and oil of Aquilaria agallocha
Journal Title: Haya: The Saudi Journal of Life Sciences - Year 2016, Vol 1, Issue 1
Abstract
Abstract: The present study conducted for Aquilaria agallocha of family Thymelaeaceae for anti-arthritic activity. The ethanolic extract of Aquilaria agallocha (EEAA) leaves and the Aquilaria agallocha oil (AAO) from Heart Wood were studied using in-vitro BSA denaturation method and in-vivo Freund's adjuvant induced arthritic rat model. The inhibition of protein denaturation in-vitro model and paw volume, hematological parameters and radiology of hind legs were studied. EEAA (100, 250 and 500 µg/ml) showed 34.09%, 36.95% and 43.13% inhibition respectively and AAO (100, 250 and 500 µg/ml) showed 23.68%, 48.21% and 56.71% inhibition of protein denaturation respectively and are comparable with Diclofenac (100, 250 and 500 µg/ml) showed 39.58%, 75.83% and 77.51% . In FA Arthritic model EEAA (200 mg/kg and 400 mg/kg) inhibited the increase in paw volume and maximum inhibition were 21.20% and 25.34% respectably on 21th day. The percentage of inhibition was found gradually increasing with the day of treatment. Treated group with AAO (125 mg/kg and 250 mg/kg) inhibited the increase in paw volume and maximum inhibition were 19.78% and 27.88% respectably on 13th and 21th day respectably. Further the hematological and radiological also studies revealed the antiarthritic activity of EEAA and AAO. Keywords: Aquilaria agallocha, anti-arthritic activity, Freund's adjuvant, BSA denaturation.
Authors and Affiliations
Habibur Rahman, M. Chinna Eswaraiah, A. M. Dutta
Keywords
Related Articles
- EP ID EP382898
- DOI -
- Views 187
- Downloads 0
Dye Yielding Woody Plants along the National Highway from Parwanoo to Kaurik in Himachal Pradesh
Abstract:Himachal Pradesh experience diverse climatic condition due to wide variation in altitude ranging from 350 m in the southern tract to over 6500 m in the main Himalaya and in the area lying in it6. National highwa...
Farmers' Participatory Demonstration of Nitrogen Application Methods during T. Aman Season in Barisal Region of Bangladesh
Abstract: The demonstration was carried out at the farmers’ fields of Barisal region of Bangladesh to evaluate the effectiveness of fertilizer application methods in T. Aman rice in non-saline tidal flooded soil during J...
Climbers of Rampur and Kotgarh Forest Division of Shimla District, Himachal Pradesh
Abstract:Himachal Pradesh is lying between 30.22' to 33.12' North latitudes and 75.47' to 79.04’ East longitudes. The area of the state is 55,673 km2 with almost mountainous elevations ranging from 350-6500 m above the m...
Phytochemical Studies on Ipomoea sepiariaRoxb
Abstract:Ipomoea sepiariaRoxb., also known as Purple heart glory is a slender vine belonging to family Convolvulaceae. In Sanskrit it is known as lakshmana, in hindi as Bankalmi and in Malayalam as Tirutali. It is one am...
Impact of Giardiasis on Plasma Protein profile of infected children
Abstract: Giardia is a common protozoan parasite infecting children in developing countries and is known to result protein loss in infected children. The objective of this study was to assess the association of plasma pr...