Anti-cancer effect of EGCG and its mechanisms
Journal Title: Functional Foods in Health and Disease - Year 2016, Vol 6, Issue 2
Abstract
Epidemiological analysis demonstrated there are negative correlation between green tea consumption and the risk of non-Hodgkin lymphoma1 and prostate cancer. Recent studies show (–)-epigallocatechin-3-O-gallate (EGCG), major green tea polyphenol suppresses the proliferation of cancer cells and induces cell death without adversely affecting normal cells. Several molecular mechanisms of its effect have been suggested. Recently, 67-kDa laminin receptor (67LR) was identified as the sensing molecule for EGCG. Surprisingly, 67LR overexpresses in cancer cells play the crucial role in the selective toxicity of EGCG. Moreover, possible downstream mechanisms were suggested in 67LR-dependent the anti-cancer effect of EGCG. This review focused on the molecular mechanism of EGCG and the novel strategy to amplify its effect.
Authors and Affiliations
Motofumi Kumazoe, Hirofumi Tachibana
The effects of whey protein,resistant starch and nutrition education on body weight
Background: Obesity is widely recognized as one of the most critical health threats to families and children across the country. Obesity is a very serious health problem for people in Louisiana and especially in African...
Accumulation of solvent-soluble and solvent-insoluble antioxidant phenolics in edible bean sprouts: implication of germination
Background: Edible bean sprouts are popular fresh vegetables widely recognized for their nutritional quality. However, while their antioxidant capacity and phenolic composition in both solvent-soluble and solvent-insolub...
An in vitro study on the regulation of oxidative protective genes in human gingival and intestinal epithelial cells after treatment with salmon protein hydrolysate peptides
Background: Under physiological conditions, molecular oxygen generates reactive oxygen species (ROS) as metabolic by-products. In the absence of an adequate defense mechanism, the accumulation of ROS leads to cell membra...
Topical applied nutraceutical antioxidant formulation reduces ocular oxidative stress
Background: Oral nutraceutical antioxidants have shown disappointing clinical results in reducing oxidation-induced age-related cataract and other ocular diseases. Based on the hypothesis that nutraceuticals do not adequ...
Efficacy of a novel herbal composition licorice flavonoid oil in subject with metabolic syndrome: a randomized double-blind placebo-controlled clinical study
Background: In order to evaluate the effects of licorice flavonoid oil (LFO) on waist circumference, blood pressure, lipid profile, body fat composition, body weight, body mass index (BMI), and fasting blood glucose in p...