ANTI-DEPRESSANT POTENTIAL OF GHIYA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Lagenaria siceraria (Cucurbitaceae), popularly known as bottle gourd, lauki or ghiya, is a climbing plant, which bears hard-shelled and bottle-shaped gourds as fruits. Ghiya forms an excellent diet for people having digestive problems being rich in vitamins, iron and minerals. Since, it contains low calories, bottle gourd is an awesome foodstuff for shedding extra calories. The fruit possesses diuretic, emetic, and refrigerant properties. The ghiya (lauki) juice is helpful in constipation, premature graying hair, urinary disorders and insomnia. However, there are no reports in literature pertaining to CNS actions of Lagenaria siceraria fruit. In the light of above, the present study was undertaken to test the anti-depressant potential of Lagenaria siceraria juice (LSJ). Lagenaria siceraria juice was administered at various concentrations ranging from 4%-16% v/v orally to Swiss mice (30g), once daily for 15 successive days. The anti-depressant activity was measured using Forced Swim Test (FST) and Tail Suspension Test (TST). The efficacy of Lagenaria siceraria was compared to standard anti-depressant drugs viz: fluoxetine (20mg/kg, p.o), imipramine (15mg/kg, p.o) and phenelzine (20 mg/kg, p.o). Lagenaria siceraria significantly reduced the immobility time of mice in both FST and TST. Prazosin, Baclofen, Sulpiride and p-CPA significantly antagonized this reduction in immobility duration. Furthermore, Lagenaria siceraria juice inhibited the monoamine oxidase (MAO) enzyme and reduced significantly malondialdehyde (MDA) levels. These findings reveal the anti-depressant potential of ghiya.
Authors and Affiliations
Satbir Kaur , Pardeep Azad , Milind Parle
Keywords
Related Articles
- EP ID EP119629
- DOI -
- Views 103
- Downloads 0
MICRONEEDLE: AS A FUTURE PROSPECTIVE TOOL
Optimization of drug delivery through human skin is important in modern therapy. With the limitations of oral drug delivery and the pain and needle phobias associated with traditional injections, drug delivery research h...
DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR DETERMINATION OF ESLICARBAZEPINE IN ESLICARBAZEPINE ACETATE TABLETS
A simple, precise, rapid and accurate stability indicating reverse phase high performance liquid chromatography has been developed and validated for the estimation of Eslicarbazepine Acetate in tablet dosage form. Separa...
DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF KETOPROFEN AND THIOCOLCHICOSIDE IN SOLID ORAL DOSAGE FORM
A simple, accurate, precise, economical and cost-effective UV Spectrophotometric method has been developed for simultaneous estimation of Ketoprofen and Thiocolchicoside in solid oral dosage form and validated as per Int...
INDUCED MUTAGENESIS IN ABELMOSCHUS MOSCHATUS (L.) MEDIK
Dry seeds (cultivar I – tall, branched, moisture content 3.5%; cultivar II – dwarf, unbranched, moisture content 1.5%) of Abelmoschus moschatus (L.) Medik (Family: Malvaceae; Common name: Ambrette; English name: Musk mal...
POPULATION PHARMACOKINETICS OF ANTIRETROVIRAL AGENTS: AN OVERVIEW
Despite significant advances in Highly Active Antiretroviral Therapy (HAART) during the past few years, challenges like virologic and/or immunologic failures, adverse effects of medications; drug-drug interactions, viral...